{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:13:23Z","timestamp":1777918403270,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000008","name":"health canada","doi-asserted-by":"publisher","award":["2122-HQ-000066"],"award-info":[{"award-number":["2122-HQ-000066"]}],"id":[{"id":"10.13039\/501100000008","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Palliat Med"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study leverages the Province of Quebec (Canada)\u2019s 2014 End-of-Life Care Act, which regulates the use of continuous palliative sedation and mandates its reporting, to describe its use at a population-based level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To describe the demographic and clinical characteristics of patients who received continuous palliative sedation, and to examine variabilities in clinical practice across diagnoses, indications, and care settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective convenience cohort of patients who received continuous palliative sedation until death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting\/participants:<\/jats:title>\n                    <jats:p>A total of 1005 patients\u2019 reporting forms from academic and regional hospitals and hospices between January 1st, 2016 and March 31st, 2022 were analyzed, representing 12% of all reported continuous palliative sedations performed in the Province of Quebec.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The sample was 51% male, median age of 73\u2009years (IQR 64\u201381). Most (45%) received continuous palliative sedation in academic hospitals, 40% in hospices, and 15% in regional hospitals, but none in chronic care institutions or at home. Cancer was the most prevalent diagnosis (78%). The main indications were psychological\/existential distress (57%), respiratory distress (34%), pain (28%), and delirium (24%); half had more than one form of distress. Overall median duration was 2\u2009days (IQR 1\u20135), significantly longer in cases of psychological\/existential distress (3\u2009days, IQR 1\u20137;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Medications commonly used were methotrimeprazine (74%), midazolam (69%), and lorazepam (48%), frequently in combination. 93% of patients died peacefully, while 6% experienced incomplete symptom relief, and 1%, complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The study demonstrated that standardization in the practice of continuous palliative sedation can be achieved across diverse clinical settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02692163251403417","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T10:10:55Z","timestamp":1769422255000},"page":"358-368","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Demographic and clinical characteristics, practices, and outcomes of continuous palliative sedation: A multi-setting, province-wide retrospective cohort study"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0843-0366","authenticated-orcid":false,"given":"Bruno","family":"Gagnon","sequence":"first","affiliation":[{"name":"Oncology Division, CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval Research Center, Quebec, Canada"},{"name":"Department of Family Medicine and Emergency Medicine, Universit\u00e9 Laval Cancer Research Center, Quebec, Canada"},{"name":"Sustainable Health Research Center, VITAM, Quebec, Canada"},{"name":"R\u00e9seau Qu\u00e9b\u00e9cois de recherche en soins palliatifs et de fin de vie (RQSPAL), Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7479-1560","authenticated-orcid":false,"given":"James","family":"Downar","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa, 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