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Whilst deprescribing may help reduce these medication-related issues, supporting evidence in this population group is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To synthesise evidence on the outcomes of deprescribing in people with life-limiting conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Systematic review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data source:<\/jats:title>\n                    <jats:p>MEDLINE, Embase, Scopus, PsycINFO and CINAHL were searched. Original studies published between Jan 2000 and Dec 2024 in English were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>\n                      A total of 17,457 hits were screened, of which 46 original studies met the inclusion criteria. Most eligible studies were pre-post interventional (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200914) or cohort studies (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200914), conducted primarily in nursing homes or long-term care facilities (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200920) and hospitals (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200916). The majority originated from North America (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200920) and Australia (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20097). A wide range of outcome variables were examined, with a primary focus on clinical outcomes. All studies assessing the impact on the number of medications used reported either a reduction in overall medication burden or inappropriate medications (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200915), or no significant change (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20093). Regarding mortality, most studies (10 studies) reported no impact, while 3 studies each reported increased and decreased mortality. For other outcomes, the majority of studies reported that deprescribing had no effect.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This systematic review suggests that deprescribing offers some benefits, including reduced medication burden and costs in people with life-limiting conditions. While there is no strong evidence for harm, a small proportion of patients reported increased risks, so careful monitoring is essential. Further research should explore how deprescribing outcomes vary by disease condition and medication type.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02692163261416281","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T01:54:09Z","timestamp":1771811649000},"page":"490-513","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Outcomes of deprescribing for people with life-limiting conditions: A systematic review"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1822-3969","authenticated-orcid":false,"given":"Rajeev","family":"Shrestha","sequence":"first","affiliation":[{"name":"NIHR Newcastle Patient Safety Research Collaboration, Newcastle University, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Shaw","sequence":"additional","affiliation":[{"name":"NIHR Newcastle Patient Safety Research Collaboration, Newcastle University, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0418-9843","authenticated-orcid":false,"given":"Liam","family":"Mullen","sequence":"additional","affiliation":[{"name":"NIHR Newcastle Patient Safety Research Collaboration, Newcastle University, Newcastle upon Tyne, UK"},{"name":"Northumbria Healthcare NHS Foundation Trust, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sinclair","sequence":"additional","affiliation":[{"name":"NIHR Newcastle Patient Safety Research Collaboration, Newcastle University, Newcastle upon Tyne, UK"},{"name":"Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicity","family":"Dewhurst","sequence":"additional","affiliation":[{"name":"NIHR Newcastle Patient Safety Research Collaboration, Newcastle University, Newcastle upon Tyne, UK"},{"name":"Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK"},{"name":"St Oswald\u2019s Hospice, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Todd","sequence":"additional","affiliation":[{"name":"NIHR Newcastle Patient Safety Research Collaboration, Newcastle University, Newcastle upon Tyne, UK"},{"name":"School of Pharmacy, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,22]]},"reference":[{"key":"e_1_3_2_2_2","unstructured":"Palliative Care Dictionary. 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