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Relevant value propositions and the applicability of conventional economic evaluation methods, however, may differ from other healthcare fields.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To synthesise and critically appraise context-specific economic evaluations with comprehensive methodological and quality lenses including decision-making aspects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>We conducted a systematic review of published palliative and end-of-life economic evaluations following a registered, peer-reviewed protocol (CRD42020148160). Cost-effectiveness results, methods, reporting quality (CHEERS), study quality (CHEC) and decision-making contexts were summarised narratively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources:<\/jats:title>\n                    <jats:p>The databases EMBASE, HTA-Database, MEDLINE, and NHS-EE-Database were searched between 2010 and 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 4190 identified references, 46 studies were included. Overall, 59% of the studies stemmed from four countries (UK, Canada, the Netherlands, USA), 54% were trial-based economic evaluations, 59% investigated cancer-related interventions, 41% were conducted in hospital settings, 63% were cost-utility analyses with 83% using EQ-5D for QALY-calculations. Studies typically took a health (and social) care perspective (63%) with 58% corresponding to national health technology assessment decision-making requirements. Of the evaluated interventions, 51% were cost-effective. Reporting quality (52%\u201396%) and study quality (56%\u201394%) greatly varied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Economic evaluations in palliative and end-of-life care settings mainly adhered to commonly required decision-making frameworks. This may result in sub-optimal analytical perspectives leading to important missed consequences, omitted alternative value considerations, and ignorance of some existing context-specific methodological recommendations. Developing and promoting consensus-based, context-specific methodological recommendations would be crucial to enhance the appropriateness of economic evaluation evidence in this context.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02692163261418546","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T05:58:33Z","timestamp":1772085513000},"page":"885-907","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Economic evaluations in the palliative and end-of-life care settings: A systematic review of existing evidence, methods and quality"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7574-8097","authenticated-orcid":false,"given":"Claudia","family":"Fischer","sequence":"first","affiliation":[{"name":"Department of Health Economics, Center for Public Health, Medical University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4224-6688","authenticated-orcid":false,"given":"Elisabeth","family":"Saly","sequence":"additional","affiliation":[{"name":"Department of Health Economics, Center for Public Health, Medical University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1183-8410","authenticated-orcid":false,"given":"Michael","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Health Economics, Center for Public Health, Medical University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6415-4488","authenticated-orcid":false,"given":"Eva Katharina","family":"Masel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Palliative Care, Medical University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9279-8627","authenticated-orcid":false,"given":"Judit","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Health Economics, Center for Public Health, Medical University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"e_1_3_3_3_2","first-page":"17","volume-title":"Global atlas of palliative care","author":"Knaul FM","year":"2020","unstructured":"Knaul FM, Radbruch L, Connor SR, et al. 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