{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:29:19Z","timestamp":1787164159080,"version":"build-2736575974"},"reference-count":34,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Palliat Med"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Dyspnea is a frequent and distressing symptom in people with cancer. High-flow nasal oxygen has been shown to relieve dyspnea and could offer several advantages over conventional oxygen delivery devices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To assess the effectiveness of high-flow nasal oxygen compared with other medical oxygen or air delivery devices on dyspnea in people with cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This study was designed as a systematic review and meta-analysis and was registered prospectively with PROSPERO (CRD42021265395).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources:<\/jats:title>\n                    <jats:p>EMBASE, MEDLINE and Web of Science electronic databases were searched from inception to February 23, 2025. Randomized controlled trials and controlled clinical trials evaluating the effectiveness of high-flow nasal oxygen in adults with cancer were screened, and data were independently extracted by three authors. The primary outcome was the mean change in dyspnea scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Seven trials (374 patients) met the inclusion criteria. Six trials (272 patients) were included in the meta-analysis. Most trials were at a high risk of bias or had some concerns. The meta-analysis showed that high-flow nasal oxygen significantly improved dyspnea compared to other medical oxygen or air delivery devices (SMD: \u22120.60; 95% CI: \u22121.02 to \u22120.17;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200965%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.014). Sub-group analysis showed that the improvement was only visible in hypoxemic patients (SMD: \u20130.87; 95% CI \u20141.33 to \u20140.40;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200958.7%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.089).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>High-flow nasal oxygen could be an additional therapeutic option for alleviating dyspnea in hospitalized people with advanced cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02692163261422559","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T06:06:56Z","timestamp":1772086016000},"page":"823-832","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["High-flow nasal oxygen for the relief of persistent dyspnea in adult patients with cancer: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3430-370X","authenticated-orcid":false,"given":"Lisa","family":"Hentsch","sequence":"first","affiliation":[{"name":"Division of Palliative Medicine, Department of Rehabilitation and Geriatrics, Geneva University Hospitals, Switzerland"},{"name":"Faculty of Medicine, University of Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4295-3024","authenticated-orcid":false,"given":"Ivan","family":"Guerreiro","sequence":"additional","affiliation":[{"name":"Division of Pneumology, Department of Medicine, Geneva University Hospitals, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Gonzalez Jaramillo","sequence":"additional","affiliation":[{"name":"Palliative and Supportive Care Clinic, Ente Ospedaliero Cantonale, Bellinzona, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Singovski","sequence":"additional","affiliation":[{"name":"Division of Palliative Medicine, Department of Rehabilitation and Geriatrics, Geneva University Hospitals, Switzerland"},{"name":"Faculty of Medicine, University of Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8428-1388","authenticated-orcid":false,"given":"Isabelle","family":"Santana","sequence":"additional","affiliation":[{"name":"Division of Palliative Care, St John\u2019s Hospice and St Elizabeth Hospital, London, England, UK"},{"name":"Marie Curie Palliative Care Research Department, University College London, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Cocetta","sequence":"additional","affiliation":[{"name":"SC Rete Cure Palliative e Hospice, Area Isontina, ASUGI, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6270-1035","authenticated-orcid":false,"given":"Tanja","family":"Fusi-Schmidhauser","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Geneva, Switzerland"},{"name":"Palliative and Supportive Care Clinic, Ente Ospedaliero Cantonale, Bellinzona, Switzerland"},{"name":"Department of Internal Medicine, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale, Switzerland"},{"name":"Department of Rehabilitation and Geriatrics, Geneva University Hospitals, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2014.09.003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2015.07.020"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201111-2042ST"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2013.11.011"},{"issue":"14","key":"e_1_3_2_6_2","first-page":"1064","article-title":"Effect of opioids for breathlessness in heart failure: a systematic review and meta-analysis","volume":"109","author":"Gaertner J","year":"2023","unstructured":"Gaertner J, Fusi-Schmidhauser T, Stock S, et al. Effect of opioids for breathlessness in heart failure: a systematic review and meta-analysis. Heart Br Card Soc 2023; 109(14): 1064\u20131071.","journal-title":"Heart Br Card Soc"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.20206"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.14282"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201707-548FR"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.04.007"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.09.024"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-1097-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3906\/sag-2007-228"},{"key":"e_1_3_2_16_2","unstructured":"Ryan R Synnort A Prictor et al. Cochrane Consumers and Communication Group Data extraction template for included studies [Internet]. La Trobe University 2016. http:\/\/cccrg.cochrane.org\/author-resources"},{"key":"e_1_3_2_17_2","unstructured":"Hedges LV Olkin I. Statistical methods for meta-analysis [Internet]. Academic Press 1985. https:\/\/www.sciencedirect.com\/book\/monograph\/9780080570655\/statistical-methods-for-meta-analysis#book-info"},{"key":"e_1_3_2_18_2","unstructured":"Higgins JP Li T Deeks JJ. Chapter 6: Choosing effect measures and computing estimates of effect. https:\/\/www.cochrane.org\/authors\/handbooks-and-manuals\/handbook\/current\/chapter-06 (2024)"},{"key":"e_1_3_2_19_2","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J","year":"1998","unstructured":"Cohen J (ed.). Statistical power analysis for the behavioral sciences. 2nd ed. Erlbaum, 1998.","edition":"2"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-021-01310-0"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_3_2_23_2","unstructured":"Critical Appraisal Skills Programme. CASP (Randomised Controlled Trial) Checklist [Internet]. 2018. https:\/\/casp-uk.net (accessed 4 mars 2019)."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2019.09.009"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13624"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13622"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2012.10.284"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-022-07330-w"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2013.00863","article-title":"Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs","volume":"4","author":"Lakens D.","year":"2013","unstructured":"Lakens D. Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Front Psychol 2013; 4: 863.","journal-title":"Front Psychol"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2025.108057"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2023.11.009"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2025.08.033"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.118521"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00038914"}],"container-title":["Palliative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02692163261422559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02692163261422559","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02692163261422559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T18:48:32Z","timestamp":1780253312000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02692163261422559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1177\/02692163261422559"],"URL":"https:\/\/doi.org\/10.1177\/02692163261422559","relation":{},"ISSN":["0269-2163","1477-030X"],"issn-type":[{"value":"0269-2163","type":"print"},{"value":"1477-030X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]}}}