{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T17:54:28Z","timestamp":1791741268463,"version":"4.3.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Andrew Davies\u2019 research"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Palliat Med"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Circadian rest-activity rhythm disorders, affecting up to 60% of patients with advanced cancer, are associated with poor clinical outcomes. As disease severity correlates with circadian disruption, a multi-modal approach may be necessary to improve circadian rhythmicity in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To assess the feasibility, primarily in relation to recruitment, retention, usability and acceptability, of a multi-modal, non-pharmacological intervention in patients with advanced cancer and a circadian rest-activity rhythm disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A prospective, single arm, outpatient feasibility study took place over 8-weeks incorporating a clinical review, daily bright light therapy, online cognitive behavioural therapy for insomnia course, and personalised physical activity plan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings\/participants:<\/jats:title>\n                    <jats:p>Adult (\u2a7e18\u2009years old) outpatients from an acute hospital and hospice service with locally advanced or metastatic cancer and a circadian rest-activity rhythm disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Participants (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200920) completed questionnaires (80%) and accelerometry (75%) and engaged with the CBT-I course (100%), bright light therapy (80%) and physical activity plan (100%). Participants reported acceptability and usability of the intervention, with no intervention-related adverse events noted. Preliminary improvements were seen in scores for fatigue (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.003) and insomnia (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.021), and symptom-related distress scores (all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Scores also improved for social (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001), cognitive (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.006), emotional (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.012), and physical (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.046) functioning.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The study demonstrated acceptability, usability and preliminary efficacy for the intervention, and warrants further investigation with a definitive trial to assess the impact on clinical outcomes of interest.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02692163261426431","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:51:49Z","timestamp":1774327909000},"page":"845-855","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["REstoring Sleep and Energy using a mulTimodal non-pharmacological intervention in advanced Cancer: A feasibility study (RESET-C)"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6131-2997","authenticated-orcid":false,"given":"Craig","family":"Gouldthorpe","sequence":"first","affiliation":[{"name":"School of Medicine, Trinity College Dublin, Ireland"},{"name":"Academic Department of Palliative Medicine, Our Lady\u2019s Hospice &amp; Care Services, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4207-4799","authenticated-orcid":false,"given":"Andrew","family":"Davies","sequence":"additional","affiliation":[{"name":"School of Medicine, Trinity College Dublin, Ireland"},{"name":"Academic Department of Palliative Medicine, Our Lady\u2019s Hospice &amp; Care Services, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_3_4_2_2","article-title":"Symptom burden in patients with advanced cancer and a circadian rest-activity rhythm disorder","volume":"15","author":"Gouldthorpe C","year":"2025","unstructured":"Gouldthorpe C, Davies A. Symptom burden in patients with advanced cancer and a circadian rest-activity rhythm disorder. BMJ Support Palliat Care 2025; 15: A65.","journal-title":"BMJ Support Palliat Care"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15153784"},{"issue":"6","key":"e_1_3_4_4_2","first-page":"486","article-title":"Non-pharmacological interventions for sleep disturbance (\u201cinsomnia\u201d) in patients with advanced cancer: a scoping review","volume":"33","author":"Munir S","year":"2025","unstructured":"Munir S, Connolly M, Davies AN. Non-pharmacological interventions for sleep disturbance (\u201cinsomnia\u201d) in patients with advanced cancer: a scoping review. Support Care Cancer 2025; 33(6): 486.","journal-title":"Support Care Cancer"},{"issue":"12","key":"e_1_3_4_5_2","first-page":"1124","article-title":"Pharmacological interventions for sleep disturbance (\u201cinsomnia\u201d) in patients with advanced cancer receiving specialist palliative care: a scoping review","volume":"33","author":"Ryan S","year":"2025","unstructured":"Ryan S, Munir S, Davies A. Pharmacological interventions for sleep disturbance (\u201cinsomnia\u201d) in patients with advanced cancer receiving specialist palliative care: a scoping review. Support Care Cancer 2025; 33(12): 1124.","journal-title":"Support Care Cancer"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1240284","article-title":"Circadian rhythm disorders in patients with advanced cancer: a scoping review","volume":"13","author":"Gouldthorpe C","year":"2023","unstructured":"Gouldthorpe C, Power J, Davies A. Circadian rhythm disorders in patients with advanced cancer: a scoping review. Front Oncol 2023; 13: 1240284.","journal-title":"Front Oncol"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2021.101491"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2015.08.009"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10865-015-9617-6"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27445"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1352"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2020.101409"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40675-015-0021-0"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2015.07.001"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S47790"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.12703\/r\/11-4"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnetp.2022.877676"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319874900"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20110115"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14071720"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.356"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-016-0450-7"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-13-104"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291702006074"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(00)00065-4"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000901)89:5<1162::AID-CNCR26>3.0.CO;2-Y"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1037\/pas0000959"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2017.1286501"},{"key":"e_1_3_4_31_2","first-page":"76","article-title":"The effects of seasons and weather on sleep patterns measured through longitudinal multimodal sensing","volume":"4","author":"Mattingly SM","year":"2021","unstructured":"Mattingly SM, Grover T, Martinez GJ, et al. The effects of seasons and weather on sleep patterns measured through longitudinal multimodal sensing. Nature 2021; 4: 76.","journal-title":"Nature"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.3109\/03014460.2013.827737"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12904-020-00542-z"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951519000312"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2016.11.010"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2024.101925"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-25322-y"}],"container-title":["Palliative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02692163261426431","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02692163261426431","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02692163261426431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T09:46:16Z","timestamp":1780220776000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02692163261426431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1177\/02692163261426431"],"URL":"https:\/\/doi.org\/10.1177\/02692163261426431","relation":{},"ISSN":["0269-2163","1477-030X"],"issn-type":[{"value":"0269-2163","type":"print"},{"value":"1477-030X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]}}}