{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T09:41:07Z","timestamp":1792489267567,"version":"4.5.0"},"reference-count":70,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Palliat Med"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Palliative sedation is used to relieve refractory suffering in terminally ill patients. Propofol, an intravenous anesthetic, may offer advantages due to its rapid onset and short half-life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To evaluate the role of propofol in palliative sedation, focusing on symptom control, sedation depth, survival time, safety, and ethical implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Systematic review registered in PROSPERO (CRD42025643575; February 6, 2025).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources:<\/jats:title>\n                    <jats:p>Scopus, MEDLINE, and Web of Science were searched for English-language studies (2005\u20132024) on propofol use in adult terminally ill patients. Studies comparing propofol with other sedatives or non-sedated controls were included; those involving anesthetic or intensive care settings were excluded. Risk of bias and certainty of evidence were assessed. Results were synthesized narratively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Ten non-randomized studies were included (observational, cross-sectional, cohort, case series, and before-and-after designs), mostly of moderate quality, conducted in Europe (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20097) involving 4072 patients (28,3% received palliative sedation), mainly with cancer. Symptom control was reported in 73%\u2013100% of cases, target sedation depth was achieved in 52%\u2013100%, although outcome definitions and measurement methods varied. Survival ranged from 19\u2009h to 38\u2009days. Propofol was used alone (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20094) or with other sedatives (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20096). Respiratory depression was the main safety concern. Ethical issues included absence of explicit consent and rare reports of life-shortening intent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Propofol may be considered as a rescue option in selected refractory cases managed by experienced teams; however, given the low to very low certainty of available evidence, findings should be interpreted cautiously and supported by institutional protocols and further prospective research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02692163261465774","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:58:40Z","timestamp":1785484720000},"page":"1302-1321","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Propofol for palliative sedation: A systematic review of clinical outcomes, safety, and ethical implications"],"prefix":"10.1177","volume":"40","author":[{"given":"Lu\u00eds","family":"Almeida-Jardim","sequence":"first","affiliation":[{"name":"Palliative Medicine Center, Faculty of Medicine, University of Lisbon, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4665-585X","authenticated-orcid":false,"given":"Paulo","family":"Reis-Pina","sequence":"additional","affiliation":[{"name":"Palliative Medicine Center, Faculty of Medicine, University of Lisbon, Lisboa, Portugal"},{"name":"Acute Palliative Care Inpatient Unit, Local Health Unit of Santa Maria, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"World Health Organization. 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