{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:18:57Z","timestamp":1777918737071,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1994,7,1]],"date-time":"1994-07-01T00:00:00Z","timestamp":773020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Palliat Med"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:p>We have investigated the steady-state plasma concentrations of midazolam during continuous subcutaneous administration in palliative care. Using a sensitive gas chromatography with electron capture detector assay, plasma concentrations of midazolam were measured in 11 patients (median age 68 years; range 47-82 years; six females) receiving the drug by continuous subcutaneous infusion (median rate 20 mg\/day; range 10-60 mg\/day). While not significant, the infusion rate tended to decrease with increasing age of the patient (Spearman's p = \u20140.51; p = 0.11). The steady-state plasma concentration range was 10-147 ng\/ml, with a median of 30 ng\/ml. Infusion rates and plasma concentrations of midazolam were correlated (Spearman's p = 0.71 ; p &lt; 0.05). No other significant relationships were found between plasma concentrations and the variables of age, sex and liver function.<\/jats:p>","DOI":"10.1177\/026921639400800307","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T20:02:59Z","timestamp":1196107379000},"page":"231-236","source":"Crossref","is-referenced-by-count":15,"title":["Plasma concentrations of midazolam during continuous subcutaneous administration in palliative ca re"],"prefix":"10.1177","volume":"8","author":[{"given":"Martin D","family":"Bleasel","sequence":"first","affiliation":[{"name":"Tasmanian School of Pharmacy, University of Tasmania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory M","family":"Peterson","sequence":"additional","affiliation":[{"name":"Tasmanian School of Pharmacy, University of Tasmania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul F","family":"Dunne","sequence":"additional","affiliation":[{"name":"Palliative Care Unit, Repatriation General Hospital, Hobart, Tasmania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,7,1]]},"reference":[{"key":"atypb1","first-page":"533","volume":"6","author":"Khanderia U.","year":"1987","journal-title":"Clin Pharm"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91057-4"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1177\/026921638900300411"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/0885-3924(90)90020-K"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(05)80007-7"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1991.tb93848.x"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1177\/026921639100500310"},{"key":"atypb8","first-page":"115","volume":"21","author":"Peterson GM","year":"1991","journal-title":"Hosp Pharm"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198916060-00002"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)82824-8"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1989.182"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199208000-00010"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1988.31"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1007\/BF00548771"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198461010-00006"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.2.190"},{"key":"atypb17","first-page":"405","volume":"6","author":"Rinetti M.","year":"1985","journal-title":"Clin Pharm Res"}],"container-title":["Palliative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/026921639400800307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/026921639400800307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:44:53Z","timestamp":1777661093000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/026921639400800307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,7]]}},"alternative-id":["10.1177\/026921639400800307"],"URL":"https:\/\/doi.org\/10.1177\/026921639400800307","relation":{},"ISSN":["0269-2163","1477-030X"],"issn-type":[{"value":"0269-2163","type":"print"},{"value":"1477-030X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7]]}}}