{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:20:21Z","timestamp":1777918821180,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1997,5,1]],"date-time":"1997-05-01T00:00:00Z","timestamp":862444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Palliat Med"],"published-print":{"date-parts":[[1997,5]]},"abstract":"<jats:p>\n                    A prospective phase II study was conducted to define the analgesic efficacy, acceptability and toxicity of the transdermal therapeutic system (TTS) of fentanyl in Chinese patients with severe cancer-related pain. A total of 14 patients was treated with TTS fentanyl at doses ranging from 25 to 100 \u03bcg h\n                    <jats:sup>-1<\/jats:sup>\n                    ; initial doses were chosen according to their previous opioid requirement. Standard supportive therapy was given as required. A brief pain inventory (using a 10-point scale) was used to assess patients at days 0, 7 and 14. Pain control on day 14 with TTS fentanyl was successful in six patients, with a reduction in the common side-effects of other opioids and improvement in general well-being. Seven patients did not complete the 14-day trial: two developed dizziness and nausea within 3 h of application; and in five, TTS fentanyl was insufficiently flexible to control increasing pain during the first week. TTS fentanyl was effective and well tolerated in 43% of patients. Acute dizziness and nausea within the first few hours after application and the relative inflexibility of dose-adjustment both limited the use of TTS fentanyl.\n                  <\/jats:p>","DOI":"10.1177\/026921639701100308","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T20:02:59Z","timestamp":1196107379000},"page":"233-239","source":"Crossref","is-referenced-by-count":20,"title":["Transdermal fentanyl for severe cancer-related pain"],"prefix":"10.1177","volume":"11","author":[{"given":"Winnie","family":"Yeo","sequence":"first","affiliation":[{"name":"Department of Clinical Oncology and Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwok K","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology and Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony TC","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology and Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas WT","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology and Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sau Y","family":"Wu Nip","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology and Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip J","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology and Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,5,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198507113130205"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198906000-00008"},{"key":"atypb3","unstructured":"Buyse ME Clinical trial methodology. 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