{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T12:01:00Z","timestamp":1780142460499,"version":"3.54.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p> We describe the case of a patient who developed depression following bilateral orchidectomy for cryptorchidism. He was treated with a conventional selective serotonin reuptake inhibitor antidepressant, but continued to take St John\u2019s wort (hypericum) against medical advice. He subsequently developed a manic episode. We discuss postulated modes of action of St John\u2019s wort and the possible aetiological importance of testosterone replacement and abnormal gonadotrophin levels in this case. <\/jats:p>","DOI":"10.1177\/026988110001400113","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T23:04:54Z","timestamp":1238627094000},"page":"84-86","source":"Crossref","is-referenced-by-count":69,"title":["Mania in a patient receiving testosterone replacement post-orchidectomy taking St John\u2019s wort and sertraline"],"prefix":"10.1177","volume":"14","author":[{"given":"D. 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