{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:59:58Z","timestamp":1774450798129,"version":"3.50.1"},"reference-count":100,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p>This article briefly summarizes, within the context of a brief review of the relevant literature, the outcome of our recent rat microdialysis studies on (1) the relative importance of serotonin (5-HT)<jats:sub>1A<\/jats:sub>versus 5-HT<jats:sub>1B<\/jats:sub>autoreceptors in the mechanism of action of 5-HT reuptake blocking agents, including putative regional differences in this regard, and (2) autoreceptor responsiveness following chronic SSRI administration. First, our data are consistent with the primacy of 5-HT<jats:sub>1A<\/jats:sub>autoreceptors in restraining the elevation of 5-HT levels induced by SSRIs, whereas nerve terminal 5-HT<jats:sub>1B<\/jats:sub>autoreceptors appear to have an accessory role in this regard. Second, there is an important interplay between cell body and nerve terminal 5-HT autoreceptors, and recent findings suggest that this interplay may potentially be exploited to obtain regionally preferential effects on 5-HT neurotransmission in the central nervous system, even upon systemic drug administration. In particular, emerging data suggest that somatodendritic 5-HT<jats:sub>1A<\/jats:sub>autoreceptorand nerve terminal 5-HT<jats:sub>1B<\/jats:sub>autoreceptor-mediated feedback may be relatively more important in the control of 5-HT output in dorsal raphe-frontal cortex and median raphe-dorsal hippocampus systems, respectively. Third, 5-HT autoreceptors evidently retain the capability to limit the 5-HT transmission-promoting effect of SSRIs after chronic treatment. Thus, although the responsiveness of these sites is probably somewhat reduced, residual autoreceptor capacity still remains an effective restraint on large increases in extracellular 5-HT, even after prolonged treatment. If a further increase in extracellular 5-HT is crucial to the remission of depression in patients responding only partially to prolonged administration of antidepressants, then sustained adjunctive treatment with autoreceptor-blocking drugs may consequently prove useful in the long term.<\/jats:p>","DOI":"10.1177\/026988110001400208","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T23:04:54Z","timestamp":1238627094000},"page":"177-185","source":"Crossref","is-referenced-by-count":151,"title":["Serotonin autoreceptor function and antidepressant drug action"],"prefix":"10.1177","volume":"14","author":[{"given":"S.","family":"Hjorth","sequence":"first","affiliation":[{"name":"Institute for Physiology and Pharmacology Department of Pharmacology, G\u00f6teborg University, G\u00f6teborg, Sweden;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. J.","family":"Bengtsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kullberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Carlzon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Peilot","sequence":"additional","affiliation":[{"name":"Institute for Physiology and Pharmacology, Department of Pharmacology, G\u00f6teborg University, G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. B.","family":"Auerbach","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Rutgers University, Piscataway, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,3,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00251121"},{"key":"atypb2","first-page":"141","volume-title":"Psychopharmacology: the third generation of progress","author":"Aghajanian G K","year":"1987"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1007\/BF00167182"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(93)90125-4"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950030084009"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(95)00169-7"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00171317"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(94)00137-H"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199901)31:1<13::AID-SYN3>3.0.CO;2-Y"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890150310"},{"key":"atypb11","first-page":"101","volume":"51","author":"Bengtsson H J","year":"1997","journal-title":"Nordic J Psychiatry"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.1.37"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00383-7"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199506000-00011"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-198712001-00003"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890050206"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.155.10.1346"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(94)90083-3"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(95)00023-Y"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1007\/BF02246110"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01141-2"},{"key":"atypb22","first-page":"2059","volume":"58","author":"Cadieux R J","year":"1998","journal-title":"Am Family Physician"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1007\/BF01579067"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.67051945.x"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701420"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(94)90177-5"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701796"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890140407"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01580-X"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1007\/BF02527753"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00430-6"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb15919.x"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702546"},{"key":"atypb34","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1021\/jm970457s","volume":"41","author":"Gaster L M","year":"1998","journal-title":"J Med Chem"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68031159.x"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(97)00052-X"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00164-8"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1007\/BF00170162"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702510"},{"key":"atypb40","first-page":"239","volume-title":"Handbook of experimental pharmacology, serotoninergic neurons and 5-HT receptors in the CNS","author":"Hamon M","year":"1997"},{"key":"atypb41","first-page":"131","volume":"4","author":"Hensler J G","year":"1991","journal-title":"Neuropsychopharmacology"},{"key":"atypb42","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00579-2"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005259"},{"issue":"598","key":"atypb44","first-page":"1","volume":"142","author":"Hillegaart V","year":"1991","journal-title":"Acta Physiol Scand"},{"key":"atypb45","first-page":"203","volume-title":"Advances in the biosciences","author":"Hjorth S","year":"1992"},{"key":"atypb46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb03217.x"},{"key":"atypb47","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00185-9"},{"key":"atypb48","first-page":"1109","volume":"24","author":"Hjorth S","year":"1998","journal-title":"Soc Neurosci Abstr"},{"key":"atypb49","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)90346-8"},{"key":"atypb50","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(94)90062-0"},{"key":"atypb51","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01585-1"},{"key":"atypb52","first-page":"143","volume-title":"4th IUPHAR Satellite Meeting on Serotonin","author":"Hjorth S"},{"key":"atypb53","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(85)90207-2"},{"key":"atypb54","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(86)90344-4"},{"key":"atypb55","doi-asserted-by":"publisher","DOI":"10.1007\/BF00179315"},{"key":"atypb56","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0022-3565(25)38162-0","volume":"265","author":"Hjorth S","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"atypb57","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90177-R"},{"key":"atypb58","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(96)00779-0"},{"key":"atypb59","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(97)00050-6"},{"key":"atypb60","first-page":"110","volume":"53","author":"Hjorth S","year":"1999","journal-title":"Nordic J Psychiatry"},{"key":"atypb61","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90914-U"},{"key":"atypb62","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)90344-1"},{"key":"atypb63","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00730-E"},{"key":"atypb64","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(95)02159-0"},{"key":"atypb65","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(97)00060-9"},{"key":"atypb66","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/S0022-3565(25)38637-4","volume":"268","author":"Jolas T","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"atypb67","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/S0022-3565(25)10650-2","volume":"274","author":"Kreiss D S","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"atypb68","doi-asserted-by":"publisher","DOI":"10.1007\/BF00176767"},{"key":"atypb69","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-10-04037.1992"},{"key":"atypb70","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199904000-00014"},{"key":"atypb71","doi-asserted-by":"publisher","DOI":"10.1007\/BF00166906"},{"key":"atypb72","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903140312"},{"key":"atypb73","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.69020791.x"},{"key":"atypb74","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb16878.x"},{"key":"atypb75","author":"Millan M J","year":"1999","journal-title":"J Psychopharmacol"},{"key":"atypb76","doi-asserted-by":"crossref","first-page":"3S","DOI":"10.1097\/00004714-198712001-00002","volume":"7","author":"Molliver M E","year":"1987","journal-title":"J Clin Psychopharmacol"},{"key":"atypb77","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00646-X"},{"key":"atypb78","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-3623(96)00460-0"},{"key":"atypb79","first-page":"128","volume":"52","author":"Peilot H","year":"1998","journal-title":"Nordic J Psychiatry"},{"key":"atypb80","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)08007-5"},{"key":"atypb81","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/00004714-199908000-00002","volume":"19","author":"Rasanen P","year":"1999","journal-title":"J Clin Psychopharmacol"},{"key":"atypb82","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00061-2"},{"key":"atypb83","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68062593.x"},{"key":"atypb84","doi-asserted-by":"publisher","DOI":"10.1016\/0893-133X(95)00240-E"},{"key":"atypb85","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(96)13199-2"},{"key":"atypb86","first-page":"1","volume-title":"Antidepressants: new pharmacological strategies","author":"Romero L","year":"1997"},{"key":"atypb87","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90635-1"},{"key":"atypb88","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890200306"},{"key":"atypb89","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702059"},{"key":"atypb90","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(96)00968-5"},{"key":"atypb91","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701235"},{"key":"atypb92","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(88)90380-9"},{"key":"atypb93","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(88)90079-2"},{"key":"atypb94","first-page":"1081","volume-title":"Psychopharmacology: the fourth generation of progress","author":"Thase M E","year":"1995"},{"key":"atypb95","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199703000-00003"},{"key":"atypb96","first-page":"93","volume":"37","author":"Vinar O","year":"1996","journal-title":"Homeostasis Health Dis"},{"key":"atypb97","doi-asserted-by":"publisher","DOI":"10.1007\/BF00175785"},{"key":"atypb98","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(96)00579-1"},{"key":"atypb99","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S0026-895X(25)09248-X","volume":"41","author":"Yocca F D","year":"1992","journal-title":"Mol Pharmacol"},{"key":"atypb100","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199712000-00002"}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/026988110001400208","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/026988110001400208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T03:26:17Z","timestamp":1740972377000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/026988110001400208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":100,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,3]]}},"alternative-id":["10.1177\/026988110001400208"],"URL":"https:\/\/doi.org\/10.1177\/026988110001400208","relation":{},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"value":"0269-8811","type":"print"},{"value":"1461-7285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,3]]}}}