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The release of serotonin can be blocked by serotonin uptake inhibitors such as citalopram. It is unknown to what extent this mechanism is also responsible for the physiological side-effects of MDMA seen in humans. We investigated the effect of citalopram pretreatment (40 mg i.v.) on vegetative and cardiovascular effects of MDMA (1.5 mg\/kg p.o.) in a double-blind placebo-controlled study in 16 healthy volunteers. MDMA moderately increased blood pressure and heart rate, slightly elevated body temperature and produced a broad range of acute and shortterm side-effects. Citalopram reduced all these MDMA-induced physiological changes except for body temperature. These findings suggest that physiological effects of MDMA in humans are partially due to an interaction of MDMA with the serotonin carrier and a subsequent release of serotonin.<\/jats:p>","DOI":"10.1177\/026988110001400313","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T23:04:54Z","timestamp":1238627094000},"page":"269-274","source":"Crossref","is-referenced-by-count":121,"title":["The serotonin uptake inhibitor citalopram reduces acute cardiovascular and vegetative effects of 3, 4-methylenedioxymethamphetamine (\u2018Ecstasy\u2019) in healthy volunteers"],"prefix":"10.1177","volume":"14","author":[{"given":"Matthias E.","family":"Liechti","sequence":"first","affiliation":[{"name":"University Hospital of Psychiatry Zurich, Research Unit, PO Box 68, CH-8029 Z\u00fcrich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz X.","family":"Vollenweider","sequence":"additional","affiliation":[{"name":"University Hospital 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