{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:29:02Z","timestamp":1777858142903,"version":"3.51.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>Eighty-one panic disorder patients with or without agoraphobia were treated with flexible doses of clomipramine under single-blind conditions. Fifty-seven (70.3%) reached operational criteria for full remission in 16.2 \u00b1 6.5 weeks, with a mean dose of 89.1 \u00b1 8.2 mg\/day. Fifty-four (81%) of them received a continuous post-remission maintenance treatment at full doses of clomipramine for 4\u20136 months. No patient relapsed during the clomipramine maintenance phase. Their medication was then tappered and discontinued with placebo substitution under double-blind conditions. Fifty-one (63%) patients were followed-up until relapse or recurrence for up to 3 years, with periodic assessments. Three different outcome groups were identified: the first (n = 19, 19; 37.2%) experienced an early\/immediate relapse (5.2 \u00b1 4.9 weeks after drug discontinuation); the second group (n= 22, 22; 43.1%) experienced recurrence after 42.9 \u00b1 35 weeks following discontinuation; and the third group (n = 10, 10; 19.6%) remained assymptomatic and functionally well throughout the follow-up. Predictors of early relapse were: (1) higher baseline score in the Beck Depression Inventory; (2) higher global score on the phobic avoidance scale after the full remission criteria; and (3) the need for higher clomipramine doses to reach full remission. The need for long-term or intermittent maintenance for most patients is emphasized.<\/jats:p>","DOI":"10.1177\/026988110101500103","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T19:04:54Z","timestamp":1238612694000},"page":"13-17","source":"Crossref","is-referenced-by-count":18,"title":["A dose-finding and discontinuation study of clomipramine in panic disorder"],"prefix":"10.1177","volume":"15","author":[{"given":"Francisco","family":"Lotufo-Neto","sequence":"first","affiliation":[{"name":"Institute of Psychiatry and Departament of Psychiatry, University of S\u00e3o Paulo Medical School, Brazil; Caixa Postal 3671 Departamento de Psiquiatria 01060\u2014970 S\u00e3o Paulo Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio","family":"Bernik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato 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