{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:29:04Z","timestamp":1777858144961,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2001,5,1]],"date-time":"2001-05-01T00:00:00Z","timestamp":988675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:p>We investigated the safety, tolerability and efficacy of nefazodone and paroxetine in the continuation phase of treatment of depression. The study comprised a double-blind, parallel-group comparison over 4 months, of patients who had previously improved following random allocation to nefazodone or paroxetine during an 8-week acute treatment study. Assessments included Clinical Global Impression Scales, Hamilton Rating Scales for Depression and Anxiety, Montgomery-Asberg Depression Rating Scale and the Patient Global Assessment Scale, in addition to a review of reported adverse events, vital sign measurements, electrocardiograms and clinical laboratory tests. One hundred and eight patients participated in the continuation study (53 received paroxetine, 55 nefazodone) and 73 completed treatment. No clinically relevant differences in antidepressant efficacy were seen. Headache and somnolence were the most common reported adverse events in both treatment groups. Both nefazodone and paroxetine maintain their efficacy in continuation treatment, and both are generally well tolerated.<\/jats:p>","DOI":"10.1177\/026988110101500303","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T19:04:54Z","timestamp":1238612694000},"page":"161-165","source":"Crossref","is-referenced-by-count":12,"title":["A randomized, double-blind controlled comparison of nefazodone and paroxetine in the treatment of depression: safety, tolerability and efficacy in continuation phase treatment"],"prefix":"10.1177","volume":"15","author":[{"given":"David S.","family":"Baldwin","sequence":"first","affiliation":[{"name":"Community Clinical Sciences Research Division, Faculty of Medicine, Health and Biological Sciences, University of Southampton, Southampton; University Department of Psychiatry Royal South Hants Hospital Graham Road Southampton UK;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Hawley","sequence":"additional","affiliation":[{"name":"Hertfordshire Neuroscience Research Group, University of Hertfordshire, Hertfordshire"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Mellors","sequence":"additional","affiliation":[{"name":"Bristol-Myers Squibb Company, Hounslow, Middlesex, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"On behalf of the CN104-070 study group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,5,1]]},"reference":[{"key":"atypb1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1987","edition":"3"},{"key":"atypb2","first-page":"1","volume-title":"Long-term treatment of depression","author":"Angst J","year":"1992"},{"key":"atypb3","first-page":"165","volume":"30","author":"Anton S F","year":"1994","journal-title":"Psychopharmacol Bull"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1038\/npp.1994.14"},{"issue":"2","key":"atypb5","first-page":"46","volume":"57","author":"Baldwin D S","year":"1996","journal-title":"J Clin Psychiatry"},{"key":"atypb6","volume-title":"European College of Neuropsychopharmacology (ECNP)","author":"Burns T"},{"issue":"2","key":"atypb7","first-page":"2","volume":"57","author":"Cohn C K","year":"1996","journal-title":"J Clin Psychiatry"},{"key":"atypb8","first-page":"31","volume-title":"Depression: neurobiological, pyschopathological and therapeutic advances","author":"Duggan C F","year":"1997"},{"key":"atypb9","first-page":"311","volume":"26","author":"Eison A S","year":"1990","journal-title":"Psychopharmacology (Berlin)"},{"issue":"2","key":"atypb10","first-page":"53","volume":"57","author":"Feiger A","year":"1996","journal-title":"J Clin Psychiatry"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199901000-00002"},{"key":"atypb12","first-page":"234","volume":"55","author":"Fontaine R","year":"1994","journal-title":"J Clin Psychiatry"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810330075011"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.3109\/13651509809115372"},{"key":"atypb15","first-page":"76","volume-title":"US Department of Health, Education and Welfare publication (ADM)","author":"Guy W","year":"1976"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"atypb18","first-page":"499","volume-title":"Depression: neurobiological, psychopathological and therapeutic advances","author":"Kasper S","year":"1997"},{"key":"atypb19","first-page":"451","volume-title":"In Proceedings of the Annual Congress of the European College of Neuropsychopharmacology","author":"Mendels J"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"atypb21","unstructured":"Montgomery S A, Montgomery D B (1992) In Montgomery S A, Rouillon F (eds), Long-term treatment of depression, pp. 53\u201379. 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