{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:29:17Z","timestamp":1777858157841,"version":"3.51.4"},"reference-count":70,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>This study investigated the chronic use (6.3 \u00b1 0.5 years; mean \u00b1 SEM) of therapeutic doses of clomipramine (57.0 \u00b1 8.0 mg\/day) by outpatients with panic disorder\/agoraphobia who were currently in remission to assess impairment of memory and psychomotor functions. In addition, the association between test performance and serum levels of clomipramine (CMI) and its active metabolite desmethylclomipramine (DCMI) was also assessed. Patients and healthy volunteers matched for sex, age and educational level were submitted to rating scales and to memory and psychomotor tests. There was no significant difference between groups regarding any variable, except for metamemory. Significant associations were found between (i) longer-term clomipramine treatment and poorer performance in the implicit test and (ii) higher serum levels of clomipramine or desmethylclomipramine, or both (CMI + DCMI) and lower performance in central executive tests and metamemory. The results showed that low doses of CMI chronically administered to panic patients are associated with diminished metamemory and impaired priming and working memory. Further investigations are needed to confirm these results and to determine whether the chronic use of higher therapeutic doses of tricyclic antidepressants is associated with more intense deleterious effects on memory and psychomotor functions.<\/jats:p>","DOI":"10.1177\/026988110201600305","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T19:04:54Z","timestamp":1238612694000},"page":"220-226","source":"Crossref","is-referenced-by-count":11,"title":["Memory performance in panic disorder patients after chronic use of                 clomipramine"],"prefix":"10.1177","volume":"16","author":[{"given":"Stefania Caldeira","family":"de Carvalho","sequence":"first","affiliation":[{"name":"Departamento de Farmacologia, Instituto de Ci\u00eancias                         Biom\u00e9dicas, Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Marcourakis","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00f5es em Neurologia, Hospital das                         Cl\u00ednicas, Faculdade de Medicina (LIM-15), Universidade de                         S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rinaldo","family":"Artes","sequence":"additional","affiliation":[{"name":"Departamento de Estat\u00edstica, Universidade de S\u00e3o                         Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarice","family":"Gorenstein","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, Instituto de Ci\u00eancias                         Biom\u00e9dicas, Instituto de Psiquiatria, Hospital das Clinicas,                         Faculdade de Medicina (LIM-23), Universidade de S\u00e4o Paulo, Brazi;                         LIM-23, Instituto de Psiquiatria HC-FMUSP Caixa Postal 3671 CEP 01060-970                         S\u00e3o Paulo, SP, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,5,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00265843"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/0149-7634(94)00068-C"},{"key":"atypb3","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994","edition":"4"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1736359"},{"key":"atypb5","volume-title":"Working memory","author":"Baddeley A D","year":"1986"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-7421(08)60452-1"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199506000-00003"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050753"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(91)90179-P"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1980.tb00946.x"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245787"},{"key":"atypb13","unstructured":"Biaggio A M B, Natal\u00edcio L (1979) Manual para o                 invent\u00e1rio de ansiedade tra\u00e7o-estado (IDATE). Centro Editor de                 Psicologia Aplicada-CEPA, Rio de Janeiro"},{"key":"atypb14","first-page":"17","volume":"25","author":"Bond A J","year":"1972","journal-title":"Psychopharmacologia"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050680"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1999.tb05384.x"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700011077"},{"key":"atypb18","first-page":"24","volume":"38","author":"Correa D D","year":"1988","journal-title":"Arq Bras Psic"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1007\/s002130051051"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199300810-00006"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244116"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199004000-00005"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199904)14:4<291::AID-GPS902>3.0.CO;2-7"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1159\/000271221"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199300810-00002"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1017\/S0021963097001753"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1177\/026988119300700402"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-198902000-00006"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199409000-00002"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1177\/026988119500900404"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1037\/0278-7393.11.3.501"},{"key":"atypb32","volume-title":"ECDEU assessment manual for psychopharmacology","author":"Guy W","year":"1976"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1177\/026988119500900309"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700043993"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199403001-00005"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1207\/s15324826an0602_5"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199405030-00005"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1007\/s007020050006"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1007\/BF00440847"},{"key":"atypb41","doi-asserted-by":"publisher","DOI":"10.1177\/026988110101500103"},{"key":"atypb42","doi-asserted-by":"publisher","DOI":"10.1177\/026988119300700403"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1177\/026988119901300105"},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.148.1.23"},{"key":"atypb45","first-page":"295","volume":"27","author":"Meyers B S","year":"1991","journal-title":"Psychopharmacol Bull"},{"key":"atypb46","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199208000-00007"},{"key":"atypb47","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-198901000-00002"},{"issue":"5","key":"atypb48","first-page":"38","volume":"57","author":"Oxman T E","year":"1996","journal-title":"J Clin Psychiatry"},{"key":"atypb49","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199408000-00002"},{"key":"atypb50","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(91)90038-T"},{"issue":"2","key":"atypb51","first-page":"57","volume":"58","author":"Pollack M H","year":"1997","journal-title":"J Clin Psychiatry"},{"issue":"20","key":"atypb52","first-page":"4","volume":"60","author":"Pollock B G","year":"1999","journal-title":"J Clin Psychiatry"},{"key":"atypb53","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199612000-00003"},{"key":"atypb54","first-page":"532","volume":"6","author":"Pomp\u00e9ia S","year":"1996","journal-title":"Behav Pharmacol"},{"issue":"9","key":"atypb55","first-page":"14","volume":"54","author":"Preskorn S H","year":"1993","journal-title":"J Clin Psychiatry"},{"key":"atypb56","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199400910-00006"},{"key":"atypb57","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199812001-00004"},{"key":"atypb58","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315137"},{"key":"atypb59","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1975175515"},{"key":"atypb60","first-page":"214","volume":"10","author":"Sepp\u00e4l\u00e4 T","year":"1978","journal-title":"Ann Clin Res"},{"key":"atypb61","volume-title":"Manual for the State-Trait Anxiety Inventory","author":"Spielberger C D","year":"1970"},{"key":"atypb62","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245119"},{"key":"atypb63","doi-asserted-by":"publisher","DOI":"10.1007\/s002130051042"},{"key":"atypb64","doi-asserted-by":"publisher","DOI":"10.1002\/hup.470060202"},{"key":"atypb65","doi-asserted-by":"publisher","DOI":"10.1126\/science.2296719"},{"key":"atypb66","doi-asserted-by":"publisher","DOI":"10.1080\/00223980.1945.9917223"},{"key":"atypb67","volume-title":"Manual for the Wechsler adult intelligence scale","author":"Wechsler D A","year":"1955"},{"key":"atypb68","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810180089012"},{"key":"atypb69","first-page":"291","volume":"27","author":"Young R C","year":"1991","journal-title":"Psychopharmacol Bull"},{"key":"atypb70","first-page":"523","volume":"24","author":"Zelinski E M","year":"1988","journal-title":"Psychopharmacol Bull"}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/026988110201600305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/026988110201600305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:08:29Z","timestamp":1777507709000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/026988110201600305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":70,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["10.1177\/026988110201600305"],"URL":"https:\/\/doi.org\/10.1177\/026988110201600305","relation":{},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"value":"0269-8811","type":"print"},{"value":"1461-7285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5]]}}}