{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:29:14Z","timestamp":1777858154635,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>Major depression is associated with both hypothalamic-pituitary-adrenal (HPA) axis overactivity and immune system activation. Depression is a common occurrence following interferon (IFN)-\u03b1 treatment. While IFN-\u03b1 is known to stimulate the HPA axis, little is known about the effects of exogenous IFN-\u03b1 in humans on the proinflammatory cytokine interleukin (IL)-6, a marker of immune system activation. This study examined the acute effects of IFN-\u03b1 on cortisol and IL-6 release, and the time course of any changes in these variables. Serum cortisol and plasma IL-6 were assessed in healthy volunteers over an 8-h period following 3 million units subcutaneous IFN-\u03b1 or placebo using a double-blind, placebo-controlled crossover design. IFN-\u03b1 resulted in a significant increase in both cortisol and IL-6. Regular sampling over 8 h did not delineate any sequential effect of the rise in these variables over time. We conclude that IFN-\u03b1 acutely stimulates both the HPA axis and proinflammatory cytokine release. The hypothesis that the effect of IFN-\u03b1 on the HPA axis is indirect and mediated by IL-6 was not supported by this study. Our findings are nonetheless of relevance to the aetiology of depression following IFN-\u03b1.<\/jats:p>","DOI":"10.1177\/026988110201600307","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T19:04:54Z","timestamp":1238612694000},"page":"230-234","source":"Crossref","is-referenced-by-count":23,"title":["Acute effects of low-dose interferon-\u03b1 on serum cortisol and plasma interleukin-6"],"prefix":"10.1177","volume":"16","author":[{"given":"Eugene M.","family":"Cassidy","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Eire; Department of Neuropsychiatry, Room 32, Maudsley Hospital, Denmark Hill, London SE5 8AZ, 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