{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:29:26Z","timestamp":1777858166945,"version":"3.51.4"},"reference-count":65,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:p>Although both vasopressin and stress have been implicated in the course of schizophrenia, it is unknown whether schizophrenic patients have altered stress-induced function of the vasopressinergic system. We examined the effects of acute metabolic stress induced by pharmacological doses (40 mg\/kg) of 2-deoxyglucose (2DG) on plasma concentrations of vasopressin in 13 patients with schizophrenia (with no history of polydipsia and hyponatremia) and 12 healthy control subjects. Baseline vasopressin levels were lower in the schizophrenic patients and progressively increased in both groups throughout the 60 min following 2DG administration to a similar absolute amount, thus remaining lower in the schizophrenic group. Concomitantly, patients with schizophrenia had significantly higher 2DG-induced plasma homovanillic acid (HVA) and 5-hydroxyindoleacetic acid levels. Vasopressin responses correlated positively and significantly with the HVA responses in schizophrenics and with the pituitary-adrenal axis responses in controls. These results suggest two different patterns of neuroendocrine alterations in schizophrenia, namely a relatively normal vasopressin response to 2DG despite significantly decreased baseline levels and exaggerated responses of the peripheral dopaminegic and serotonergic systems in the face of normal baseline concentrations.<\/jats:p>","DOI":"10.1177\/02698811030173014","type":"journal-article","created":{"date-parts":[[2003,9,25]],"date-time":"2003-09-25T16:10:51Z","timestamp":1064506251000},"page":"317-323","source":"Crossref","is-referenced-by-count":23,"title":["Effects of Acute Metabolic Stress on the Peripheral Vasopressinergic System                in Schizophrenia"],"prefix":"10.1177","volume":"17","author":[{"given":"Igor","family":"Elman","sequence":"first","affiliation":[{"name":"Behavioral Psychopharmacology Research Laboratory, McLean Hospital,                        Harvard Medical School, Belmont, MA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Lukas","sequence":"additional","affiliation":[{"name":"Behavioral Psychopharmacology Research Laboratory, McLean Hospital,                        Harvard Medical School, Belmont, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan E.","family":"Shoaf","sequence":"additional","affiliation":[{"name":"Otsuka Maryland Research Institute, Rockville, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Rott","sequence":"additional","affiliation":[{"name":"Medstar Cardiovascular Research Institute, Washington, DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caleb","family":"Adler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cincinnati College of Medicine                        Cincinnati, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Breier","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, and, Department of Psychiatry, Indiana                        University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,9,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1006\/frne.1994.1013"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(00)00196-8"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1126\/science.6143403"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1210\/endo-107-6-1975"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1210\/endo-107-6-1970"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-53-5-935"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1159\/000118483"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(89)90066-8"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1993.01820190043005"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1159\/000124925"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1159\/000126185"},{"key":"atypb12","doi-asserted-by":"crossref","unstructured":"de Goeij D C E, Dijkstra H, Tilders F J H (1991) Chronic psychosocial stress enhances vasopressin, but not corticotropin-releasing factor, in the external zone of the median eminence of male rats: relationship to subordinate status . 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