{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:29:29Z","timestamp":1777858169855,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p>Extracts of the herb St John\u2019s Wort have been shown to reduce alcohol intake in alcohol-preferring rats, but it is not known which of the constituent(s) are responsible for this effect. In this study, the effect of a crude methanolic extract ofHypericum perforatum(negligible hyperforin content) on alcohol drinking in C57BL\/6J alcohol-preferring mice was compared with that of a hyperforin-rich extract (45% hyperforin) prepared by extracting the herb with supercritical carbon dioxide. The dose of the hyperforin-rich extract required to significantly reduce 10% ethanol intake (5 mg\/kg) was 125-fold less than that required for the crude extract (625 mg\/kg), and was comparable to the dose of fluoxetine (10 mg\/kg) required to produce a similar effect. None of these agents significantly affected water intake. These results suggest that the effects of H. perforatumextracts on alcohol drinking behaviour are due to the hyperforin content of the herb rather than to other, more polar constituents. Hyperforin is an unstable compound and this study also highlights the effect of different methods of extract preparation on hyperforin content.<\/jats:p>","DOI":"10.1177\/0269881103174018","type":"journal-article","created":{"date-parts":[[2004,4,21]],"date-time":"2004-04-21T21:27:18Z","timestamp":1082582838000},"page":"403-408","source":"Crossref","is-referenced-by-count":15,"title":["Correlation of Hyperforin Content of Hypericum Perforatum(St John\u2019s                 Wort) Extracts with Their Effects On Alcohol Drinking in C57Bl\/6J Mice: A                 Preliminary Study"],"prefix":"10.1177","volume":"17","author":[{"given":"C. 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