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While the selective effects of serotonin and catecholamine depletion on such processes have been investigated, the effects of simultaneous depletion of these monoamines on cognition remain unclear. This is of particular interest given that multiple neurotransmitter abnormalities have been implicated in many psychiatric disorders. The aim of the current study was to examine the effects of lowered brain monoamine function on cognitive performance, using the technique of amino acid precursor depletion. The study was a double-blind, placebo-controlled design in which 20 healthy female subjects were tested under a combined monoamine depletion condition (CMD) and a balanced control condition (B). Cognitive testing was conducted at baseline and 5 h post-depletion. The CMD condition relative to the B condition resulted in deficits in digit vigilance (accuracy and reaction time), a measure of sustained attention. There were no effects on measures of learning and memory or psychomotor function. These findings suggest that simultaneously depleting the availability of brain serotonin and catecholamines in healthy female subjects selectively impairs sustained attention, without affecting other cognitive domains.<\/jats:p>","DOI":"10.1177\/0269881104040215","type":"journal-article","created":{"date-parts":[[2004,4,21]],"date-time":"2004-04-21T21:27:18Z","timestamp":1082582838000},"page":"21-31","source":"Crossref","is-referenced-by-count":24,"title":["Simultaneous Depletion of Serotonin and Catecholamines Impairs Sustained                Attention in Healthy Female Subjects without Affecting Learning and Memory"],"prefix":"10.1177","volume":"18","author":[{"given":"Cathy","family":"Matrenza","sequence":"first","affiliation":[{"name":"Neuropsychopharmacology Laboratory, Brain Sciences Institute, Swinburne                        University of Technology, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay-Maree","family":"Hughes","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Laboratory, Brain Sciences Institute, Swinburne                        University of Technology, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew H.","family":"Kemp","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Laboratory, Brain Sciences Institute, Swinburne                        University of Technology, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith A.","family":"Wesnes","sequence":"additional","affiliation":[{"name":"Cognitive Drug Research, CDR House Reading, Berkshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben J.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Laboratory, Brain Sciences Institute, Swinburne                        University of Technology, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep J.","family":"Nathan","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Laboratory, Brain Sciences Institute, Swinburne                        University of Technology, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2004,3,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02246237"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(92)90142-P"},{"key":"atypb3","doi-asserted-by":"crossref","unstructured":"Breier A (1999) Cognitive deficit in schizophrenia and its neurochemical basis . 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