{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:49:40Z","timestamp":1779299380332,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p>Previous studies suggest a modulatory role of serotonin (5-HT) in experimentally-induced panic attacks. In the current study, we investigated the acute effects of 5-HT precursor l-5-hydroxytryptophan (5-HTP) on the response to panicogenic challenge with cholecystokinin-tetrapeptide (CCK-4) in healthy volunteers. Thirty-two subjects were randomized to receive either 200 mg of 5-HTP or placebo with the CCK-4 challenge following in 90 min in a double-blind, parallel-group design. The results showed a nonsignificant difference between the groups in panic rate (19% after 5-HTP and 44% after placebo, p = 0.13) with a trend for lower intensity of symptoms after 5-HTP ( p = 0.08). Further analysis by gender revealed that females in the 5-HTP group had a significantly lower panic rate and intensity of cognitive symptoms whereas, in males, the effect of 5-HTP was limited to lowering the intensity of somatic panic symptoms. Thus, an increased availability of 5-HT may have a gender-dependent protective effect in CCK-4-induced panic.<\/jats:p>","DOI":"10.1177\/0269881104042619","type":"journal-article","created":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T22:12:53Z","timestamp":1088719973000},"page":"194-199","source":"Crossref","is-referenced-by-count":32,"title":["The Effect of 5-Hydroxytryptophan on Cholecystokinin-4-Induced Panic Attacks                 in Healthy Volunteers"],"prefix":"10.1177","volume":"18","author":[{"given":"Eduard","family":"Maron","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Tartu, Tartu, Estonia.,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Innar","family":"T\u00f5ru","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Tartu, Tartu, 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