{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:29:59Z","timestamp":1777858199784,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p>Quetiapine, an atypical antipsychotic, is effective for psychosis in younger patients, with limited adverse effects reported. This open-label naturalistic study was conducted to assess the 4-week efficacy and safety of quetiapine for treatment of geriatric psychosis. Clinical efficacy was evaluated using the Brief Psychiatric Rating Scale (BPRS) and Clinical Global Impression Improvement (CGI-I) instruments before and after 4 weeks of quetiapine treatment. The sample population consisted of 100 geropsychiatric inpatients with psychosis, with the therapeutic evaluation completed by 91. Eighty-one of these 91 patients (89.0%) experienced mild-to-substantial improvement, as determined from the CGI-I. Further, a mean reduction in BPRS score of 39.5% (from baseline) was also determined. The mean daily dose of quetiapine for the fourth week was 276.1 177.2mg\/day (range 50-800). Higher quetiapine dosages were administered for patients with functional psychoses compared to an analogous group with organic mental disorders. The most common adverse effects were somnolence (30.0%), lower-limb weakness (28.0%) and dizziness (27.0%). Body weight and fasting triglyceride were significantly elevated after quetiapine treatment (2.2% and 8.9% from baseline, respectively). Based on the results of this study, it appears that quetiapine is an efficacious and safe treatment for geriatric inpatients with psychosis, however, there is a wide dosing range and optimal dosage is diagnosis-dependent.<\/jats:p>","DOI":"10.1177\/0269881105056669","type":"journal-article","created":{"date-parts":[[2005,11,4]],"date-time":"2005-11-04T08:17:38Z","timestamp":1131092258000},"page":"661-666","source":"Crossref","is-referenced-by-count":18,"title":["The efficacy and safety of quetiapine for treatment of geriatric psychosis"],"prefix":"10.1177","volume":"19","author":[{"given":"Cheng-Hung","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital and Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Jen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital and Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen-Ping","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital and Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,11,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200118010-00004"},{"key":"atypb2","first-page":"233","volume":"7","author":"Chouinard G","year":"1980","journal-title":"Am J Neurol Sci"},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"Folstein M F","year":"1975","journal-title":"J Psychiatr Res"},{"issue":"8","key":"atypb4","first-page":"31","volume":"61","author":"Garver D L","year":"2000","journal-title":"J Clin Psychiatry"},{"key":"atypb5","unstructured":"Guy W (1976) ECDEU assessment manual for psychopharmacology. 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