{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:11:35Z","timestamp":1791403895308,"version":"4.3.3"},"reference-count":53,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p>When mice are exposed to harmless objects such as marbles in their cage they bury them, a behaviour sometimes known as defensive burying. We investigated the effect of an acute dose of MDMA (\u00e8ecstasy') and other psychoactive drugs on marble burying and also examined the effect of a prior neurotoxic dose of MDMA or p-chloroamphetamine (PCA) on burying. Acute administration of MDMA produced dose-dependent inhibition of marble burying (EC50: 7.6 \u00b5 mol\/kg). Other drugs that enhance monoamine function also produced dose-dependent inhibition: methamphetamine \u3009 PCA \u3009 paroxetine \u3009 MDMA \u3009 GBR 12909 \u3009 methylphenidate. None of these drugs altered locomotor activity at a dose that inhibited burying. A prior neurotoxic dose of MDMA, which decreased striatal dopamine content by 60%, but left striatal 5-HT content unaltered, did not alter spontaneous marble burying 18 or 40 days later. However, a neurotoxic dose of PCA which decreased striatal dopamine by 60% and striatal 5-HT by 70% attenuated marble burying 28 days later. Overall, these data suggest that MDMA, primarily by acutely increasing 5-HT function, acts like several anxiolytic drugs in this behavioural model. Long-term loss of cerebral 5-HT content also produced a similar effect. Since this change was observed only after 28 days, it is probably due to an adaptive response in the brain.<\/jats:p>","DOI":"10.1177\/0269881106058022","type":"journal-article","created":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T07:33:16Z","timestamp":1141198396000},"page":"264-271","source":"Crossref","is-referenced-by-count":14,"title":["The acute and long-term neurotoxic effects of MDMA on marble burying behaviour in mice"],"prefix":"10.1177","volume":"20","author":[{"given":"Kathryn S.","family":"Saadat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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