{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:54:52Z","timestamp":1789430092390,"version":"build-2803163510"},"reference-count":58,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p>The current study examined the long-term effect of brief exposure to 3,4-methylenedioxymethamphetamine (MDMA) on local cerebral glucose utilization (LCGU) in speci.c brain regions immediately following administration of the 5-HT2A\/2C receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI). Wistar rats (post-natal day (PND) 28, n= 24) were administered MDMA (5 mg\/kg, i.p.) or saline (1 ml\/kg, i.p.) four times daily for 2 consecutive days and core body temperature was recorded. Fifty-.ve days later and 10min following injection of DOI (1 mg\/kg, i.p.) or saline, LCGU was measured using the [14C]2-deoxyglucose (2-DG) technique. In the 4 hours following the initial injection (PND 28), MDMA-treated rats exhibited signi.cant hyperthermia compared with saline-treated controls ( p&lt; 0.05\u00f10.01). Eight weeks later, immediately following DOI challenge, LCGU was signi.cantly elevated (an increase of 47%, p&lt; 0.05) in the nucleus accumbens of MDMA\/DOI pretreated rats, compared with that in MDMA\/saline pre-treated controls. A similar trend was observed in other areas such as the lateral habenula, somatosensory cortex and hippocampal regions (percentage changes of 27\u00f141%), but these did not reach signi.cance. Blood glucose levels were signi.cantly elevated in both groups of DOI-treated rats ( p&lt; 0.05\u00f10.01). Thus, brief exposure of young rats to an MDMA regimen previously shown to cause anxiety-like behaviour and modest serotonergic neurotoxicity (Bull et al., 2004) increased DOI-induced energy metabolism in the nucleus accumbens and tended to increase metabolism in other brain regions, including the hippocampus, consistent with the induction of long-term brain region speci.c changes in synaptic plasticity.<\/jats:p>","DOI":"10.1177\/0269881106059583","type":"journal-article","created":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T07:33:16Z","timestamp":1141198396000},"page":"272-280","source":"Crossref","is-referenced-by-count":17,"title":["Pre-treatment with 3,4-methylenedioxymethamphetamine (MDMA) causes long-lasting changes in 5-HT2A receptor-mediated glucose utilization in the rat brain"],"prefix":"10.1177","volume":"20","author":[{"given":"Eleanor J.","family":"Bull","sequence":"first","affiliation":[{"name":"Institute of Neuroscience, Queen's Medical Centre, University of Nottingham, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Porkess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rigby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Hutson","sequence":"additional","affiliation":[{"name":"Merck Sharp and Dohme Neuroscience Research Centre, Harlow, Essex, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C. 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