{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:13:26Z","timestamp":1785240806195,"version":"3.55.0"},"reference-count":66,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T00:00:00Z","timestamp":1212105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p>\n                    The current study tested the hypothesis that chronic loss of inhibitory GABAergic tone in the bed nucleus of the stria terminalis (BNST), a region implicated in anxiety behavior, results in generalized anxiety disorder-like behaviors without panic-like responses (i.e., tachycardia, hypertension and tachypnea) following panicogenic stimuli (e.g., sodium lactate infusions). To test this hypothesis, the GABA synthesis inhibitor L-allylglycine (L-AG) or its inactive isomer D-AG was chronically infused into the BNST of male rats via osmotic mini-pumps. L-AG, but not D-AG, treated rats had increased anxiety-like behavior as measured by social interaction (SI) and elevated-plus maze paradigms. Restoring GABAergic tone, with 100pmoles\/100nl of muscimol (a GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptor agonist), in the BNST of L-AG treated rats attenuated L-AG-induced anxiety-like behavior in the SI test. To assess panic-like states, L-AG treated rats were intravenously infused with 0.5 M sodium lactate, a panicogenic agent, prior to assessing SI and cardiorespiratory responses. L-AG decreased SI duration again; however, sodium lactate did not induce panic-like cardiorespiratory responses. These findings demonstrate that GABA inhibition in the BNST elicits anxiety-like behavior without increasing sensitivity to lactate, thus suggesting a behavioral profile similar to that of generalized anxiety-like behavior rather than that of panic.\n                  <\/jats:p>","DOI":"10.1177\/0269881107082902","type":"journal-article","created":{"date-parts":[[2008,2,28]],"date-time":"2008-02-28T20:46:24Z","timestamp":1204231584000},"page":"633-641","source":"Crossref","is-referenced-by-count":60,"title":["Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behavior"],"prefix":"10.1177","volume":"22","author":[{"given":"TJ","family":"Sajdyk","sequence":"first","affiliation":[{"name":"Departments of Psychiatry and Biochemistry, Indiana University School of Medicine, Indianapolis, IN 46202, 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