{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:31:44Z","timestamp":1777858304486,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p>We aimed to study aripiprazole, as monotherapy and combined with other antipsychotics, in routine clinical practice, to identify patients who had a favourable clinical response. We retrospectively identified all secondary care psychiatric patient records started on aripiprazole (n = 85). We assigned Clinical Global Impression scores to measure effectiveness. We examined demographic and clinical correlates of patients who improved (CGI Improvement scores &lt; 5) versus those who did not improve (CGI \u2265 5). 56 patients (66%) received aripiprazole as monotherapy, 29 patients (34%) in combination with other antipsychotics. 52 patients (62%) received a CGI 1-4 (minimally to very much improved), 32 patients (38%) a CGI \u2265 5 (no change to very much worse). Patients who improved were less likely to have had previous or subsequent treatment with clozapine (p = 0.04). Discontinuation was due to agitation (35%), inefficacy (21%), nausea (18%) and worsening psychosis (12%). Combination with other antipsychotics resulted in less discontinuation and a lower maximum dose of aripiprazole. Aripiprazole was combined with other regular additional antipsychotics in 1\/3rd of patients. Combination and monotherapy were clinically effective in around 60% of patients. Favourable response was associated with lack of treatment resistance. Agitation was the commonest reason for discontinuation.<\/jats:p>","DOI":"10.1177\/0269881107083483","type":"journal-article","created":{"date-parts":[[2008,2,28]],"date-time":"2008-02-28T20:46:24Z","timestamp":1204231584000},"page":"778-783","source":"Crossref","is-referenced-by-count":11,"title":["Who responds to aripiprazole in clinical practice? An observational study of combination versus monotherapy"],"prefix":"10.1177","volume":"22","author":[{"given":"P.","family":"Shajahan","sequence":"first","affiliation":[{"name":"NHS Lanarkshire, Consultant Psychiatrist, The Airbles Road Centre, 49 Airbles Road, Motherwell, UK,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"MacRae","sequence":"additional","affiliation":[{"name":"NHS Greater Glasgow and Clyde, Specialist Registrar, Springpark Mental Health Resource Centre, 101 Denmark Street, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bashir","sequence":"additional","affiliation":[{"name":"NHS Lanarkshire, Staff Grade Psychiatrist, The Airbles Road Centre, 49 Airbles Road, Motherwell, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Taylor","sequence":"additional","affiliation":[{"name":"NHS Greater Glasgow and Clyde, Consultant Psychiatrist, Springpark Mental Health Resource Centre, 101 Denmark Street, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,9,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1080\/10401230490521954"},{"key":"atypb2","unstructured":"bnf.org (British National Formulary)"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1344-3"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1097\/00131746-200507000-00004"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2005.00736.x"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a006928"},{"key":"atypb7","volume":"1","author":"El-Sayeh H.G.","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2002.01331.x"},{"key":"atypb9","doi-asserted-by":"crossref","unstructured":"Guy W. 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