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Using in-vivo electrophysiological and behavioural paradigms in the rat, the effects of bifeprunox and aripiprazole were assessed on ventral tegmental area (VTA) dopamine and dorsal raphe serotonin (5-HT) cell activity and on foot shock\u2013induced ultrasonic vocalisation (USV). In VTA, bifeprunox and aripiprazole decreased (by 20\u201350%) firing of dopamine neurons. Interestingly, bursting activity was markedly reduced (by 70\u2013100%), bursting being associated with a larger synaptic dopamine release than single spike firing. Both ligands reduced inhibition of firing rate induced by the full dopamine receptor agonist apomorphine, whereas the D<jats:sub>2<\/jats:sub>receptor antagonist haloperidol prevented these inhibitory effects, confirming partial D<jats:sub>2<\/jats:sub>-like agonistic properties. On 5-HT neurons, bifeprunox was more potent than aripiprazole to suppress firing activity. The 5-HT<jats:sub>1A<\/jats:sub>receptor antagonist WAY-100,635 prevented their effects. In the USV test of anxiolytic-like activity, bifeprunox had higher potency than aripiprazole to reduce vocalisations. Both WAY-100,635 and haloperidol reversed the effects of both agonists. The present in-vivo study shows that bifeprunox is a potent partial D<jats:sub>2<\/jats:sub>-like and 5-HT<jats:sub>1A<\/jats:sub>receptor agonist reducing preferentially the phasic activity of dopamine neurons. Thus, bifeprunox would be expected to be an effective compound against positive and negative symptoms of schizophrenia.<\/jats:p>","DOI":"10.1177\/0269881108089586","type":"journal-article","created":{"date-parts":[[2008,5,31]],"date-time":"2008-05-31T01:10:57Z","timestamp":1212196257000},"page":"177-189","source":"Crossref","is-referenced-by-count":33,"title":["Effects of bifeprunox and aripiprazole on rat serotonin and dopamine neuronal activity and anxiolytic behaviour"],"prefix":"10.1177","volume":"23","author":[{"given":"L","family":"Dahan","sequence":"first","affiliation":[{"name":"Laboratory of Neuropharmacology, Faculty of Pharmacy, University of Claude Bernard Lyon I, Lyon, France"}]},{"given":"H","family":"Husum","sequence":"additional","affiliation":[{"name":"H. 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