{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:31:58Z","timestamp":1777858318411,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T00:00:00Z","timestamp":1212105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p>Abstract<\/jats:p>\n                  <jats:p>Mirtazapine augmentation to a serotonin-reuptake inhibitor has been proposed to boost antidepressant effects and more likely to induce manic switch. Such a combined antidepressant therapy strategy should be used carefully if the patient\u2019s refractoriness is attributable to mixed depressive features. Mixed depression is more difficult to be treated by antidepressant monotherapy and related to higher risk of manic switch during treatment. We report a case with no previous history of bipolar disorder, whereas developed full-blown psychotic manic symptoms soon after switch from fluoxetine to mirtazapine. The patient\u2019s premorbid characters and clinical presentations suggested an implicit bipolarity that predisposed her to a manic switch. Her manic switch was likely to be triggered by a simulated combined effect because of complex drug interactions during shifting from fluoxetine to mirtazapine. For patients in mixed depressive states, mood stabilizers are preferable to antidepressants.<\/jats:p>","DOI":"10.1177\/0269881108089807","type":"journal-article","created":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T21:10:57Z","timestamp":1212181857000},"page":"220-222","source":"Crossref","is-referenced-by-count":11,"title":["Antidepressant-associated mania: soon after switch from fluoxetine to mirtazapine in an elderly woman with mixed depressive features"],"prefix":"10.1177","volume":"23","author":[{"given":"CC","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KY","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SC","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,5,30]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60453-X"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(00)00069-9"},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/00004850-200211000-00009","volume":"17","author":"Bhanji NH","year":"2002","journal-title":"Int Clin Psychopharmacol"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00265-3"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.11.1.115"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1089\/cap.1998.8.73"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1399-5618.2003.00067.x"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/da.1085"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n1015"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.164.4.549"},{"key":"atypb11","volume-title":"Essential Psychopharmacology: Neuroscientific Basis and Practical Applications.","author":"Stahl S","year":"2000"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.11.1642"}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0269881108089807","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0269881108089807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:11:15Z","timestamp":1777507875000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0269881108089807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,30]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1177\/0269881108089807"],"URL":"https:\/\/doi.org\/10.1177\/0269881108089807","relation":{},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"value":"0269-8811","type":"print"},{"value":"1461-7285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,30]]}}}