{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:26:42Z","timestamp":1777858002804,"version":"3.51.4"},"reference-count":57,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T00:00:00Z","timestamp":1229040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p>Noradrenaline\u2014dopamine interactions mediate increases in locomotor activity, development of sensitisation and subjective effects of psychostimulant drugs. However, the modulatory effects of noradrenaline on psychostimulant-induced impulsivity are less clear. This article examined the relative roles of noradrenaline and dopamine in the modulation of methylphenidate-induced impulsive responding in rats performing the 5-choice serial reaction time task. Experiment 1 examined the systemic antagonism of methylphenidate-induced impulsivity with either propranolol, a \u03b2-adrenoreceptor blocker, or prazosin, an \u03b11-adrenoreceptor antagonist, which antagonises the locomotor activating effects of amphetamine. Propranolol completely abolished methylphenidate-induced impulsivity. This effect was centrally rather than peripherally mediated, as nadolol, a peripheral \u03b2-blocker failed to affect methylphenidate-induced premature responding. Prazosin partially attenuated the methylphenidate-mediated increase in premature responding. A second experiment examined the effects of selective anti-D\u03b2H saporin-induced cortical noradrenaline depletion on methylphenidate-induced impulsivity. Contrary to the effects of \u03b2-adrenoreceptor blockade, cortical noradrenergic depletion did not alter methylphenidate-induced impulsivity. Other experiments examined the comparative effects of selective dopamine and serotonin receptor blockade. D4 dopamine receptor blockade with systemically administered L-745,870 also attenuated methylphenidate-induced impulsivity. The other antagonists had no effect on methylphenidate-induced impulsivity. Taken together, these studies provide evidence for a modulatory role of \u03b2-adrenoreceptors on methylphenidate-induced impulsive responding.<\/jats:p>","DOI":"10.1177\/0269881108098146","type":"journal-article","created":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T21:36:32Z","timestamp":1229117792000},"page":"309-321","source":"Crossref","is-referenced-by-count":50,"title":["Methylphenidate-induced impulsivity: pharmacological antagonism by \u03b2-adrenoreceptor blockade"],"prefix":"10.1177","volume":"24","author":[{"given":"JA","family":"Milstein","sequence":"first","affiliation":[{"name":"Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JW","family":"Dalley","sequence":"additional","affiliation":[{"name":"Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, 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