{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:26:48Z","timestamp":1777858008207,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2008,11,21]],"date-time":"2008-11-21T00:00:00Z","timestamp":1227225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>Depression and anxiety frequently occur together or in extension of each other. According to a previous study in depressed inpatients, a high trait anxiety level correlated with a positive response to the diazepam test (DT) and a low trait anxiety level with a negative response to the test. The aim of this study is to investigate whether positive reaction to the DT is related to a positive response to fluvoxamine and whether a negative reaction to the test is related to positive response to imipramine. The DT was performed in 130 patients diagnosed with a depressive disorder. Following the DT, the patients were randomly assigned to double-blind treatment with either imipramine or fluvoxamine. Doses of both antidepressants were adjusted to attain predefined blood levels, and the outcome was evaluated 4 weeks after attaining these blood levels. Twenty-two patients had a positive response to the DT, whereas 108 patients had a negative response. Although a positive DT is correlated with a high level of trait anxiety, no differences in depressive symptomatology and antidepressant response were found between patients with a positive and a negative DT.<\/jats:p>","DOI":"10.1177\/0269881108099213","type":"journal-article","created":{"date-parts":[[2008,11,21]],"date-time":"2008-11-21T21:07:00Z","timestamp":1227301620000},"page":"559-563","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence of trait anxiety in a sample of depressed inpatients and its influence on response to antidepressants"],"prefix":"10.1177","volume":"24","author":[{"given":"WTCJ","family":"Heijnen","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WW","family":"van den Broek","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Erasmus Medical Centre, Rotterdam, The 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