{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:26:58Z","timestamp":1777858018882,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2009,2,24]],"date-time":"2009-02-24T00:00:00Z","timestamp":1235433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p>Schizophrenia patients have a potential increased risk of metabolic dysregulation during antipsychotic treatments. Our objective was to compare changes in prolactin and metabolic variables (glucose, lipids and weight) as a post-hoc analysis from a six-month, randomised, controlled study of olanzapine (OLZ, n = 171; 10\u201420 mg\/day) or quetiapine (QUE, n = 175; 300\u2014700 mg\/day). No statistically significant treatment group differences for baseline to endpoint mean changes in body mass index ( P = 0.209) or weight ( P = 0.250) were observed. There was a greater incidence of clinically significant weight gain (defined as \u22657% increase from baseline) in OLZ (19.2%) compared to QUE (13.2%)\u2014treated patients ( P = 0.181). No statistically significant treatment group differences for lipids and glucose variables, either as mean change from baseline to endpoint or treatment-emergent (TE) categorical changes were found ( P \u2265 0.05). Incidence rates for TE diabetes were similar between treatment groups 2.5% ( n = 4) in the OLZ-treatment group and 1.3% ( n = 2) in the QUE-treatment group ( P = 0.685). Hyperprolactinaemia was present at baseline in many patients (OLZ 32.9%; QUE 31.4%), but after 2 weeks of treatment prolactin values had reverted to normal for nearly all patients (OLZ 100%; QUE 99.4%). There were no significant treatment differences in any variable between cohorts.<\/jats:p>","DOI":"10.1177\/0269881108101783","type":"journal-article","created":{"date-parts":[[2009,2,24]],"date-time":"2009-02-24T22:47:18Z","timestamp":1235515638000},"page":"1001-1009","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of metabolic and prolactin variables from a six-month randomised trial of olanzapine and quetiapine in schizophrenia"],"prefix":"10.1177","volume":"24","author":[{"given":"C.","family":"Bushe","sequence":"first","affiliation":[{"name":"Eli Lilly and Company, Basingstoke, UK,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sniadecki","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Indianapolis, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AJ","family":"Bradley","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Basingstoke, 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