{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:27:01Z","timestamp":1777858021002,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2009,5,28]],"date-time":"2009-05-28T00:00:00Z","timestamp":1243468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:p>The deficit to reorient attention from ipsilesional to contralesional space is one key feature of the spatial neglect syndrome. As previous studies suggest that reorienting of visuospatial attention is modulated by cholinergic neurotransmission, we investigated whether cholinergic stimulation with nicotine (Nicorette\u00ae 2 mg, Pharmacia\/Pfizer, Helsingborg, Sweden) facilitates attentional reorienting in spatial neglect patients. Nine nonsmoking patients with stable neglect symptoms were investigated in a within-subject cross-over design. We used a location-cueing paradigm and analysed reaction time (RT) differences between validly and invalidly cued, as well as between neutrally cued and uncued targets as a function of hemifield and drug. Moreover, since the nicotine effect is mediated by parietal brain areas in healthy subjects, we tested whether lesion location influences the pharmacological effect. Nicotine speeded RTs in valid and invalid trials nonspecifically, without modulating the validity effect in the location-cueing task in the whole group of patients. Lesion-symptom mapping revealed a relationship between lesion site and the pharmacological effect on reorienting to contralesional space in right parietal and temporal brain regions. We conclude that in patients with chronic spatial neglect the performance in the location-cueing paradigm can be modulated by a cholinergic stimulant provided that the lesion spares right parietal and temporal cortex.<\/jats:p>","DOI":"10.1177\/0269881109105397","type":"journal-article","created":{"date-parts":[[2009,5,28]],"date-time":"2009-05-28T20:23:53Z","timestamp":1243542233000},"page":"1357-1365","source":"Crossref","is-referenced-by-count":12,"title":["The effect of nicotine on visuospatial attention in chronic spatial neglect depends upon lesion location"],"prefix":"10.1177","volume":"24","author":[{"given":"S.","family":"Vossel","sequence":"first","affiliation":[{"name":"Cognitive Neurology Section, Institute of Neuroscience and Medicine (INM-3), Research Centre J\u00fclich, J\u00fclich, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kukolja","sequence":"additional","affiliation":[{"name":"Cognitive Neurology Section, Institute of Neuroscience and Medicine (INM-3), Research Centre J\u00fclich, J\u00fclich, Germany, Department of Neurology, University Hospital Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Thimm","sequence":"additional","affiliation":[{"name":"Cognitive Neurology Section, Institute of Neuroscience and Medicine (INM-3), Research Centre J\u00fclich, J\u00fclich, Germany, Department of Neurology, University Hospital Aachen, Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CM","family":"Thiel","sequence":"additional","affiliation":[{"name":"Cognitive Neurology Section, Institute of Neuroscience and Medicine (INM-3), Research Centre J\u00fclich, J\u00fclich, Germany, Institute of Psychology, University of Oldenburg, Oldenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GR","family":"Fink","sequence":"additional","affiliation":[{"name":"Cognitive Neurology Section, Institute of Neuroscience and Medicine (INM-3), Research Centre J\u00fclich, J\u00fclich, Germany, Department of Neurology, University Hospital Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,5,28]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(99)90205-8"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1050"},{"key":"atypb3","author":"Beane, M.","year":"2002","journal-title":"Program No 674 13 Abstract Viewer\/Iternary Planner"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.09.049"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1988.107"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2001.21511"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.04.065"},{"key":"atypb8","volume-title":"Neglect-Test (NET)","author":"Fels, M.","year":"1997"},{"key":"atypb9","first-page":"371","volume":"4","author":"File, SE","year":"2001","journal-title":"Int J Neuropsychopharmacol"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.65.3.344"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2007.19.4.658"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.10.005"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2006.18.5.833"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2004.09.006"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.5.1395"},{"key":"atypb16","first-page":"57","volume":"5","author":"Halligan, PW","year":"1993","journal-title":"Crit Rev Phys Rehabil Med"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(03)00032-9"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-13179"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2008.02.122"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)01004-8"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20701"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1999.0482"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2001.25149"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(98)00012-8"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2003.11.001"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1007\/BF00613610"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000437"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1080\/00335558008248231"},{"key":"atypb30","volume-title":"Attention as an Organ System (Neurobiology of Perception and Communication: From Synapse to Society. 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