{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:35:19Z","timestamp":1789605319179,"version":"build-2803163510"},"reference-count":42,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T00:00:00Z","timestamp":1259107200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p>Cannabidiol (CBD), a Cannabis sativa constituent, may present a pharmacological profile similar to mood stabilizing drugs, in addition to anti-oxidative and neuroprotective properties. The present study aims to directly investigate the effects of CBD in an animal model of mania induced by d-amphetamine (d-AMPH). In the first model (reversal treatment), rats received saline or d-AMPH (2\u2009mg\/kg) once daily intraperitoneal (i.p.) for 14\u2009days, and from the 8th to the 14th day, they were treated with saline or CBD (15, 30 or 60\u2009mg\/kg) i.p. twice a day. In the second model (prevention treatment), rats were pretreated with saline or CBD (15, 30, or 60\u2009mg\/kg) regime i.p. twice a day, and from the 8th to the 14th day, they also received saline or d-AMPH i.p. once daily. In the hippocampus CBD (15\u2009mg\/kg) reversed the d-AMPH-induced damage and increased (30\u2009mg\/kg) brain-derived neurotrophic factor (BDNF) expression. In the second experiment, CBD (30 or 60\u2009mg\/kg) prevented the d-AMPH-induced formation of carbonyl group in the prefrontal cortex. In the hippocampus and striatum the d-AMPH-induced damage was prevented by CBD (15, 30 or 60\u2009mg\/kg). At both treatments CBD did not present any effect against d-AMPH-induced hyperactivity. In conclusion, we could not observe effects on locomotion, but CBD protect against d-AMPH-induced oxidative protein damage and increased BDNF levels in the reversal model and these effects vary depending on the brain regions evaluated and doses of CBD administered.<\/jats:p>","DOI":"10.1177\/0269881109106925","type":"journal-article","created":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T23:52:16Z","timestamp":1259193136000},"page":"274-280","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":65,"title":["Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania"],"prefix":"10.1177","volume":"25","author":[{"given":"Samira S","family":"Valvassori","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancias, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Unidade Acad\u00eamica de Ci\u00eancias da Sa\u00fade, Universidade do Extremo Sul Catarinense, Crici\u00fama, SC, Brasil."},{"name":"INCT Translational Medicine, CNPq, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Elias","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancias, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Unidade Acad\u00eamica de Ci\u00eancias da Sa\u00fade, Universidade do Extremo Sul Catarinense, Crici\u00fama, SC, Brasil."},{"name":"INCT Translational Medicine, CNPq, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"de Souza","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancias, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Unidade Acad\u00eamica de Ci\u00eancias da Sa\u00fade, Universidade do Extremo Sul Catarinense, Crici\u00fama, SC, Brasil."},{"name":"INCT Translational Medicine, CNPq, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabr\u00edcia","family":"Petronilho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancias, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Unidade Acad\u00eamica de Ci\u00eancias da Sa\u00fade, Universidade do Extremo Sul Catarinense, Crici\u00fama, SC, Brasil."},{"name":"INCT Translational Medicine, CNPq, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Dal-Pizzol","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancias, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Unidade Acad\u00eamica de Ci\u00eancias da Sa\u00fade, Universidade do Extremo Sul Catarinense, Crici\u00fama, SC, Brasil."},{"name":"INCT Translational Medicine, CNPq, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1vio","family":"Kapczinski","sequence":"additional","affiliation":[{"name":"Bipolar Disorders Programme and Laboratory of Molecular Psychiatry, Centro de Pesquisas, Hospital de Cl\u00ednicas de Porto Alegre, Porto Alegre, RS, Brasil."},{"name":"INCT Translational Medicine, CNPq, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa","family":"Trzesniak","sequence":"additional","affiliation":[{"name":"Department of Behavioral Neurosciences; 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