{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:26:57Z","timestamp":1777858017282,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2009,12,4]],"date-time":"2009-12-04T00:00:00Z","timestamp":1259884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p>This naturalistic retrospective study aims to compare effectiveness of a second-generation antipsychotic medication, risperidone, with first-generation antipsychotic medications (haloperidol and trifluoperazine) in an Asian population with first-episode schizophrenia-spectrum disorders. A total of 261 patients were assessed for time to discontinuation for any reason and specific reasons of discontinuation, controlling for baseline differences between groups. Some 90% of patients discontinued their antipsychotic medications before 18 months. Median time to discontinuation for any reason in risperidone was 69 days versus first-generation antipsychotic medications of 27 days. Specifically, the risperidone group had a longer time to discontinuation for any reason than haloperidol (HR = 0.61, p = 0.005) and trifluoperazine groups (HR = 0.63, p = 0.03), as well as a longer time to discontinuation due to intolerability of side effects than haloperidol (HR = 0.50, p = 0.008) and trifluoperazine groups (HR = 0.26, p = 0.001). There were no significant differences between medications for time to discontinuation due to lack of efficacy, patient\u2019s\/family\u2019s decisions or other reasons. We conclude that there is a very high rate of discontinuation of the initial antipsychotic medications for various reasons, with risperidone having an overall longer time to discontinuation compared with first-generation antipsychotic medications.<\/jats:p>","DOI":"10.1177\/0269881109351965","type":"journal-article","created":{"date-parts":[[2009,12,4]],"date-time":"2009-12-04T22:39:47Z","timestamp":1259966387000},"page":"973-980","source":"Crossref","is-referenced-by-count":6,"title":["Comparing effectiveness of risperidone with first-generation antipsychotic medications in patients with schizophrenia-spectrum disorders"],"prefix":"10.1177","volume":"24","author":[{"given":"Alvin","family":"Liew","sequence":"first","affiliation":[{"name":"Early Psychosis Intervention Programme, Institute of Mental Health\/ Woodbridge Hospital, Singapore,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swapna","family":"Verma","sequence":"additional","affiliation":[{"name":"Early 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