{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:27:23Z","timestamp":1777858043990,"version":"3.51.4"},"reference-count":63,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2010,2,10]],"date-time":"2010-02-10T00:00:00Z","timestamp":1265760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p>Homer1a is a glutamate-related gene whose expression is induced by antipsychotics acutely (i.e. 90\u2009min after treatment). Acute Homer1a expression is preserved after prolonged antipsychotic treatments, while the effects of short-term discontinuation after chronic antipsychotic treatment have not yet been assessed. Here, we studied early and long-term effects on gene expression by antipsychotics for Homer1a and other components of glutamatergic synapses.<\/jats:p>\n                  <jats:p>In the first paradigm, we evaluated Homer1a acute expression by single administration of antipsychotics (haloperidol 0.8\u2009mg\/kg, ziprasidone 10 and 4\u2009mg\/kg, clozapine 15\u2009mg\/kg). Haloperidol and ziprasidone induced Homer1a in the striatum. Induction by ziprasidone was dose-dependent. These results suggest that acute Homer1a expression correlates with dopaminergic affinity and motor side effects of antipsychotics. In the second paradigm, we studied antipsychotic-mediated long-term changes in Homer1a and glutamate-related genes. Rats were treated (21 days) with haloperidol 0.8\u2009mg\/kg, ziprasidone 4\u2009mg\/kg, or vehicle, and then sacrificed at 90\u2009min (early time-point) or 24\u2009h (delayed time-point) after last injection. Gene expression at these two time-points was compared. Homer1a preserved its pattern of expression at the early but not at the delayed time-point. Significant changes were also observed for PSD-95. The results suggest that Homer1a preserves its expression profile after chronic antipsychotics.<\/jats:p>","DOI":"10.1177\/0269881109358199","type":"journal-article","created":{"date-parts":[[2010,2,11]],"date-time":"2010-02-11T00:10:39Z","timestamp":1265847039000},"page":"875-887","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Pattern of acute induction of\n                    <i>Homer1a<\/i>\n                    gene is preserved after chronic treatment with first- and second-generation antipsychotics: effect of short-term drug discontinuation and comparison with Homer1a-interacting genes"],"prefix":"10.1177","volume":"25","author":[{"given":"Felice","family":"Iasevoli","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Psychiatry and Psychopharmacotherapy, Section of Psychiatry, Department of Neuroscience, University School of Medicine \u2018Federico II\u2019, Naples, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Ambesi-Impiombato","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Psychiatry and Psychopharmacotherapy, Section of Psychiatry, Department of Neuroscience, University School of Medicine \u2018Federico II\u2019, Naples, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germano","family":"Fiore","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Psychiatry and Psychopharmacotherapy, Section of Psychiatry, Department of Neuroscience, University School of Medicine \u2018Federico II\u2019, Naples, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Panariello","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Psychiatry and Psychopharmacotherapy, Section of Psychiatry, Department of Neuroscience, University School of Medicine \u2018Federico II\u2019, Naples, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Muscettola","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Psychiatry and Psychopharmacotherapy, Section of Psychiatry, Department of Neuroscience, University School of Medicine \u2018Federico II\u2019, Naples, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"de Bartolomeis","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Psychiatry and Psychopharmacotherapy, Section of Psychiatry, Department of Neuroscience, University School of Medicine \u2018Federico II\u2019, Naples, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,2,10]]},"reference":[{"key":"bibr1-0269881109358199","doi-asserted-by":"publisher","DOI":"10.1016\/S1385-299X(03)00056-4"},{"key":"bibr2-0269881109358199","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20385"},{"key":"bibr3-0269881109358199","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-14-05301.1998"},{"key":"bibr4-0269881109358199","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0022-3565(25)24594-3","volume":"244","author":"Boyson SJ","year":"1988","journal-title":"J Pharmacol Exp 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