{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:50:40Z","timestamp":1791186640158,"version":"4.1.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2010,6,11]],"date-time":"2010-06-11T00:00:00Z","timestamp":1276214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>Cognitive decline is a feature of ageing and can be defined as normal (age-associated memory impairment) or pathological (mild cognitive impairment\/Alzheimer\u2019s disease). Stimulation of selective brain-specific neuronal nicotinic acetylcholine receptors might offer symptomatic treatment for normal ageing. The objective of this study was to assess the safety, tolerability and efficacy of TC-1734 (AZD3480), a selective \u03b14\u03b22 nicotinic agonist, in the treatment of age-associated memory impairment. A randomized placebo-controlled trial was conducted in 16 community-based centers within the USA. Subjects who met objective criteria for age-associated memory impairment were recruited between November 2004 and December 2005. Subjects were randomly assigned to receive orally 25\u2009mg ( n\u2009=\u200959), 50\u2009mg ( n\u2009=\u200968) TC-1734 (AZD3480) or placebo ( n\u2009=\u200966) in a double-blind fashion for 16 weeks. Main outcome measures included routine clinical safety measures, tolerability, cognitive assessment via the Cognitive Drug Research computerized test battery and a Subject Global Impression Scale of Cognition (SCI-Cog). Two outcomes from the computerized test battery \u2013 a factor assessing attention and one assessing episodic memory, along with the SGI-Cog were defined as co-primary outcome variables. Baseline to Week 16 differences from placebo for 50\u2009mg TC-1734 (AZD3480) were considered of primary importance. For 50\u2009mg TC-1734 (AZD3480) attention factor the mean drug\u2013placebo difference was 22.9 (95% confidence interval 4.8 to 41.4) p\u2009=\u20090.01 for episodic memory factor the difference was \u22127.6 (95% confidence interval \u221214.4 to \u22120.8), p\u2009=\u20090.029, and for the SGI-Cog the difference was 0.99 (95% confidence interval 0.2 to 1.8), p\u2009=\u20090.015. As all three co-primary outcomes were positive it can be concluded the compound likely had a beneficial effect on cognition. TC-1734 (AZD3480) appeared safe and well tolerated in this study.<\/jats:p>","DOI":"10.1177\/0269881110367727","type":"journal-article","created":{"date-parts":[[2010,6,11]],"date-time":"2010-06-11T20:35:12Z","timestamp":1276288512000},"page":"1020-1029","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["A randomized double-blind study comparing 25 and 50\u2009mg TC-1734 (AZD3480) with placebo, in older subjects with age-associated memory impairment"],"prefix":"10.1177","volume":"25","author":[{"given":"Geoffrey C","family":"Dunbar","sequence":"first","affiliation":[{"name":"Targacept Inc. Winston Salem, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramana V","family":"Kuchibhatla","sequence":"additional","affiliation":[{"name":"QED Pharma, Morrisville, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Lee","sequence":"additional","affiliation":[{"name":"Stiefel Laboratories Inc, Durham, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the TC-1734 (AZD3480) AAMI Clinical Study Group (USA)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,6,11]]},"reference":[{"key":"bibr1-0269881110367727","doi-asserted-by":"crossref","unstructured":"Anderson DJ, Malysz J, Halvard J, et al. 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