{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:27:18Z","timestamp":1777858038413,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2010,5,24]],"date-time":"2010-05-24T00:00:00Z","timestamp":1274659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p>The relative risk of changes in metabolic parameters during treatment with atypical antipsychotics has not been fully investigated. Baseline-to-endpoint mean and anytime-categorical changes in metabolic parameters were evaluated in Lilly active comparator-controlled clinical trials. Olanzapine-treated patients gained significantly more baseline-to-endpoint weight versus risperidone- (3.3\u2009kg [ N\u2009=\u2009713; median exposure [ ME, days] =\u200968] versus 1.8\u2009kg [ N\u2009=\u2009697; ME\u2009=\u200965], p\u2009&lt;\u20090.001), ziprasidone- (2.8\u2009kg [ N\u2009=\u2009463; ME\u2009=\u2009168] versus \u22121.3\u2009kg [ N\u2009=\u2009443; ME\u2009=\u200989], p\u2009&lt;\u20090.001), and aripiprazole-treated patients (3.7\u2009kg [ N\u2009=\u2009273; ME\u2009=\u2009104] versus 0.5\u2009kg [ N\u2009=\u2009275; ME\u2009=\u2009187], p\u2009&lt;\u20090.001). Significantly more olanzapine-treated patients gained \u22657% of their baseline weight versus risperidone- (30.6% [ N\u2009=\u2009713; ME\u2009=\u2009169] versus 20.2% [ N\u2009=\u2009697; ME\u2009=\u2009140], p\u2009&lt;\u20090.001), ziprasidone- (30.0% [ N\u2009=\u2009463; ME\u2009=\u2009147] versus 6.5% [ N\u2009=\u2009443; ME\u2009=\u2009165], p\u2009&lt;\u20090.001), and aripiprazole-treated patients (40.3% [ N\u2009=\u2009273; ME\u2009=\u2009170] versus 16.4% [ N\u2009=\u2009275; ME\u2009=\u2009154], p\u2009&lt;\u20090.001). Olanzapine-treated patients had significantly greater baseline-to-endpoint changes in fasting triglycerides compared with ziprasidone- (0.24\u2009mmol\/L [ N\u2009=\u2009365; ME\u2009=\u2009168] versus \u22120.24\u2009mmol\/L [ N\u2009=\u2009316; ME\u2009=\u2009140], p\u2009&lt;\u20090.001) and aripiprazole-treated patients (0.28\u2009mmol\/L [ N\u2009=\u2009215; ME\u2009=\u2009195] versus \u22120.19\u2009mmol\/L [ N\u2009=\u2009210; ME\u2009=\u2009194], p\u2009&lt;\u20090.001). Olanzapine-treated patients had significantly greater baseline-to-endpoint changes in fasting glucose than ziprasidone- (0.25\u2009mmol\/L [ N\u2009=\u2009379; ME\u2009=\u2009168] versus \u22120.04\u2009mmol\/L [ N\u2009=\u2009333; ME\u2009=\u2009133], p\u2009=\u20090.016) and aripiprazole-treated patients (0.27\u2009mmol\/L [ N\u2009=\u2009227; ME\u2009=\u2009195] versus 0.04\u2009mmol\/L [ N\u2009=\u2009220; ME\u2009=\u2009194], p\u2009=\u20090.048). The study concluded that there are changes with varying frequencies and magnitude in some metabolic parameters in patients treated with olanzapine compared with other atypical antipsychotics.<\/jats:p>","DOI":"10.1177\/0269881110368872","type":"journal-article","created":{"date-parts":[[2010,5,24]],"date-time":"2010-05-24T23:14:18Z","timestamp":1274742858000},"page":"630-638","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Metabolic parameters in patients treated with olanzapine or other atypical antipsychotics"],"prefix":"10.1177","volume":"25","author":[{"given":"Olawale","family":"Osuntokun","sequence":"first","affiliation":[{"name":"Eli Lilly and Company, Indianapolis, IN, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Millen","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Indianapolis, IN, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen I","family":"Xu","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Indianapolis, IN, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludmilla A","family":"Kryzhanovskaya","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Indianapolis, IN, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Robertson-Plouch","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Indianapolis, IN, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice L","family":"Carlson","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Indianapolis, IN, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayan","family":"Acharya","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Indianapolis, IN, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara A","family":"Corya","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Indianapolis, IN, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,5,24]]},"reference":[{"issue":"7","key":"bibr1-0269881110368872","first-page":"22","volume":"62","author":"Allison DB","year":"2001","journal-title":"J Clin Psychiatry"},{"key":"bibr2-0269881110368872","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.2.596"},{"key":"bibr3-0269881110368872","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S3153"},{"key":"bibr4-0269881110368872","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000227705.56870.06"},{"issue":"12","key":"bibr5-0269881110368872","first-page":"18","volume":"68","author":"Henderson DC","year":"2007","journal-title":"J Clin 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