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In this study, single-unit extracellular recordings were used to monitor dorsal raphe nucleus (DR) 5-HT neuronal activity in anesthetized rats, under basal conditions (CTRL), in response to MLT administration, and after pinealectomy (PX) across the light\u2013dark cycle. Under basal conditions, the number of spontaneously active 5-HT neurons and their firing rate were both significantly lower in the dark phase. In the light phase, administration of MLT at low doses (0.5\u20131\u2009mg\/kg, i.v.) decreased 5-HT firing activity. This inhibitory effect of MLT was completely blocked by the MT\n                    <jats:sub>1<\/jats:sub>\n                    \/MT\n                    <jats:sub>2<\/jats:sub>\n                    receptor antagonist luzindole, but not by the selective MT\n                    <jats:sub>2<\/jats:sub>\n                    receptor antagonist 4P-PDOT, the selective 5-HT\n                    <jats:sub>1A<\/jats:sub>\n                    receptor antagonist WAY100635, or by the \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    adrenoceptor antagonist idazoxan. In the opposite experiment, PX increased 5-HT firing activity in the dark phase, and this was reversed by MLT administration (1\u2009mg\/kg, i.v.). Finally, in a forced swim test, MLT (1\u2009mg\/kg, i.p.) increased immobility time and decreased swimming behavior. Together, these results suggest that nocturnal MLT secretion imposes tonic inhibitory control over a sub-population of DR 5-HT neurons. This MLT-induced decrease in 5-HT neurotransmission may represent a biological mechanism underlying mood disorders characterized by increased MLT secretion, such as seasonal affective disorder.\n                  <\/jats:p>","DOI":"10.1177\/0269881111408460","type":"journal-article","created":{"date-parts":[[2011,7,5]],"date-time":"2011-07-05T22:10:17Z","timestamp":1309903817000},"page":"830-844","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Short-term effects of melatonin and pinealectomy on serotonergic neuronal activity across the light\u2013dark cycle"],"prefix":"10.1177","volume":"26","author":[{"given":"Sergio","family":"Dom\u00ednguez-L\u00f3pez","sequence":"first","affiliation":[{"name":"Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, Montreal, QC, 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