{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:11:47Z","timestamp":1791223907668,"version":"4.1.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T00:00:00Z","timestamp":1316649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>Depressive symptoms and episodes dominate the course of bipolar disorder. However, the therapeutic armamentarium for bipolar depression is limited. Recent evidence points to the efficacy of second generation antipsychotics (SGAs) for the treatment of bipolar depression. We conducted a systematic review and meta-analysis of the efficacy and safety of SGAs (randomized, double-blind, placebo-controlled trials; used in monotherapy) in the treatment of adult patients with bipolar depression. Publication bias was corrected for by performing similar searches using the clinical trials register of the respective pharmaceutical companies, the Cochrane Database and ClinicalTrials.gov. Seven published papers were identified on the use of aripiprazole, olanzapine and quetiapine. Internal validity of the trials was fairly good, external validity only moderate. Different outcome measures of efficacy and safety were assessed. When the individual trials were looked at, quetiapine and to a lesser extent olanzapine demonstrated significant improvement in MADRS (Montgomery\u2013\u00c5sberg Depression Rating Scale) total scores. This was not demonstrated for aripiprazole. Efficacy was hampered by adverse events, such as weight gain, akathisia and somnolence\/sedation. Both clinical heterogeneity of the included trials and statistical heterogeneity of the meta-analytic data were considerable. The number of quetiapine trials was disproportionate to the number of trials of aripiprazole and olanzapine. Further research is needed to assess differential efficacy of the different SGAs and their use in clinical practice.<\/jats:p>","DOI":"10.1177\/0269881111408461","type":"journal-article","created":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T20:16:47Z","timestamp":1316722607000},"page":"603-617","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":81,"title":["Second generation antipsychotics in the treatment of bipolar depression: a systematic review and meta-analysis"],"prefix":"10.1177","volume":"26","author":[{"given":"J\u00fcrgen","family":"De Fruyt","sequence":"first","affiliation":[{"name":"Department of Psychiatry, General Hospital Sint-Jan Brugge-Oostende AV, Brugge, Belgium"},{"name":"University Psychiatric Center \u2013 Catholic University Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Deschepper","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics, Biometrics and Process Control, Ghent University, Ghent, Belgium and Belgium Biostatistics Unit, Ghent University, Ghent, Belgium"},{"name":"Department of Psychiatry and Medical Psychology, Ghent University, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Audenaert","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Medical Psychology, Ghent University, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Constant","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Universit\u00e9 Catholique de Louvain, Woluwe-Saint-Lambert, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Floris","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, H\u00f4pital Notre-Dame, Tournai, Tournai, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Pitchot","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Li\u00e8ge, CHU of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Sienaert","sequence":"additional","affiliation":[{"name":"University Psychiatric Center \u2013 Catholic University Leuven, Kortenberg, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Souery","sequence":"additional","affiliation":[{"name":"Laboratory of Psychological Medicine, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"},{"name":"Psy Pluriel \u2013 European Center of Psychological Medicine, Uccle, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Claes","sequence":"additional","affiliation":[{"name":"University Psychiatric Center \u2013 Catholic University Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,9,22]]},"reference":[{"key":"bibr1-0269881111408461","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2005.02.018"},{"key":"bibr2-0269881111408461","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0703"},{"key":"bibr3-0269881111408461","first-page":"26","volume":"66","author":"Calabrese JR","year":"2005","journal-title":"J Clin Psychiatry"},{"key":"bibr4-0269881111408461","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.7.1351"},{"key":"bibr5-0269881111408461","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e3280119dfb"},{"key":"bibr6-0269881111408461","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2008.00625.x"},{"key":"bibr7-0269881111408461","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0514"},{"key":"bibr8-0269881111408461","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145706007413"},{"key":"bibr9-0269881111408461","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145709990344"},{"key":"bibr10-0269881111408461","doi-asserted-by":"publisher","DOI":"10.1159\/000097966"},{"key":"bibr11-0269881111408461","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-7-40"},{"key":"bibr12-0269881111408461","volume-title":"Bipolar Depression. 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