{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:28:02Z","timestamp":1777858082044,"version":"3.51.4"},"reference-count":68,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2011,7,5]],"date-time":"2011-07-05T00:00:00Z","timestamp":1309824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>Anticonvulsants, notably those which modulate GABA activity, have shown efficacy in reducing aggressive behavior. Previously, we found dose-related decreases in human aggressive responding following acute tiagabine administration. Here, we examined the effects of chronic tiagabine over a 5-week period. Twelve individuals at increased risk for aggressive and violent behavior (currently on parole\/probation with personality and\/or substance use disorders) were randomly assigned to placebo ( n\u2009=\u20096) or an escalating dose sequence of placebo, 4\u2009mg, 8\u2009mg, 12\u2009mg, placebo ( n\u2009=\u20096). Data were analyzed using both frequentist and Bayesian mixed models, evaluating aggressive behavior as a function of time, dose condition, and their interaction. For aggressive responding, there was a significant interaction of drug condition and time. Aggression in the tiagabine condition decreased for each additional week in the study, while participants in the placebo condition failed to demonstrate similar change over time. For monetary-reinforced responding, no drug or drug by time interactions were observed, suggesting specificity of drug effects on aggression. The small number of subjects limits the generality of the findings, and previous studies with tiagabine are limited to acute dosing and case report investigations. However, the present data provide an indication that tiagabine merits further examination as an agent for management of impulsive aggression.<\/jats:p>","DOI":"10.1177\/0269881111408962","type":"journal-article","created":{"date-parts":[[2011,7,5]],"date-time":"2011-07-05T22:10:17Z","timestamp":1309903817000},"page":"982-993","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Chronic tiagabine administration and aggressive responding in individuals with a history of substance abuse and antisocial behavior"],"prefix":"10.1177","volume":"26","author":[{"given":"Joshua L","family":"Gowin","sequence":"first","affiliation":[{"name":"Program in Neuroscience, Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles E","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Psychiatry & Behavioral Sciences, School of Medicine, University of Texas Health Science Center, Houston, TX, USA"},{"name":"Center for Clinical Research & Evidence Based Medicine, University of Texas Health Science Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph L","family":"Alcorn","sequence":"additional","affiliation":[{"name":"Program in Neuroscience, Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan C","family":"Swann","sequence":"additional","affiliation":[{"name":"Program in Neuroscience, Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, TX, USA"},{"name":"Department of Psychiatry & Behavioral Sciences, School of Medicine, University of Texas Health Science Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F Gerard","family":"Moeller","sequence":"additional","affiliation":[{"name":"Program in Neuroscience, Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, TX, USA"},{"name":"Department of Psychiatry & Behavioral Sciences, School of Medicine, University of Texas Health Science Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott D","family":"Lane","sequence":"additional","affiliation":[{"name":"Program in Neuroscience, Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, TX, USA"},{"name":"Department of Psychiatry & Behavioral Sciences, School of Medicine, University of Texas Health Science Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,7,5]]},"reference":[{"key":"bibr1-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.10.979"},{"key":"bibr2-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199710000-00002"},{"key":"bibr3-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911109107"},{"key":"bibr4-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(01)00220-7"},{"key":"bibr5-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.153908"},{"key":"bibr6-0269881111408962","volume-title":"MCMC Estimation in MlwiN","author":"Browne WJ","year":"2009"},{"key":"bibr7-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.63.3.452"},{"key":"bibr8-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00309-6"},{"key":"bibr9-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1007\/s002130100812"},{"key":"bibr10-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1201\/b14206-13"},{"key":"bibr11-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1007\/s002130100915"},{"key":"bibr12-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1901\/jeab.1992.58-577"},{"key":"bibr13-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1590-z"},{"key":"bibr14-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(97)00119-4"},{"key":"bibr15-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1586\/ern.10.71"},{"key":"bibr16-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.10.004"},{"key":"bibr17-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(77)90177-0"},{"key":"bibr18-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2006.00035.x"},{"key":"bibr19-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.08.019"},{"key":"bibr20-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1016\/0191-8869(85)90144-8"},{"key":"bibr21-0269881111408962","volume-title":"Structured Clinical Interview for DSM-IV Axis I Disorders: Non patient edition (SCID-NP)","author":"First MB","year":"1996"},{"key":"bibr22-0269881111408962","volume-title":"Structured Clinical Interview for DSM-IV Axis II Personality Disorders, (SCID-II)","author":"First MB","year":"1997"},{"key":"bibr23-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1201\/9781420057478"},{"key":"bibr24-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2006.07.003"},{"key":"bibr25-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-1987-3"},{"key":"bibr26-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-198505000-00014"},{"key":"bibr27-0269881111408962","doi-asserted-by":"publisher","DOI":"10.4140\/TCP.n.2007.1004"},{"key":"bibr28-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2005.15.682"},{"key":"bibr29-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.17.2.252"},{"key":"bibr30-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.3.621"},{"key":"bibr31-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300153"},{"key":"bibr32-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003499.pub3"},{"key":"bibr33-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1006\/ebeh.2002.0319"},{"key":"bibr34-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.6.669"},{"key":"bibr35-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007667.pub2"},{"key":"bibr36-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-002-0080-z"},{"key":"bibr37-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2009.01.002"},{"key":"bibr38-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011591"},{"key":"bibr39-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2008.04.004"},{"key":"bibr40-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1177\/0269881107078489"},{"issue":"3","key":"bibr41-0269881111408962","first-page":"36","volume":"64","author":"Malcolm RJ","year":"2003","journal-title":"J Clin Psychiatry"},{"key":"bibr42-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3500-07.2007"},{"key":"bibr43-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1330.021"},{"key":"bibr44-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2003.04.002"},{"key":"bibr45-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1998.tb05896.x"},{"key":"bibr46-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301283"},{"key":"bibr47-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1080\/00048670701261251"},{"key":"bibr48-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.11.044"},{"key":"bibr49-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-1"},{"key":"bibr50-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1002\/9780470752463.ch11"},{"key":"bibr51-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1177\/0269881109103799"},{"key":"bibr52-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(81)80011-1"},{"key":"bibr53-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(81)80004-4"},{"key":"bibr54-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1016\/0160-2527(95)00018-6"},{"key":"bibr55-0269881111408962","volume-title":"Mental Disorder and Crime","author":"Robins LN","year":"1993"},{"key":"bibr56-0269881111408962","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.encep.2007.05.005","volume":"34","author":"Saias T","year":"2008","journal-title":"Encephale"},{"key":"bibr57-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.07111774"},{"key":"bibr58-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(98)00040-2"},{"key":"bibr59-0269881111408962","first-page":"S52","volume":"3","author":"Sorgi P","year":"1991","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"bibr60-0269881111408962","volume-title":"Assessment of Anger: The State-Trait Anger Scale, Advances in Personality Assessment","volume":"2","author":"Spielberger CD","year":"1983"},{"key":"bibr61-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-009-0043-3"},{"key":"bibr62-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1037\/1064-1297.13.1.72"},{"key":"bibr63-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.5.393"},{"key":"bibr64-0269881111408962","first-page":"761","volume":"41","author":"Swanson JW","year":"1990","journal-title":"Hosp Community Psychiatry"},{"key":"bibr65-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890140210"},{"key":"bibr66-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2008.07.006"},{"key":"bibr67-0269881111408962","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2007.05.028"},{"key":"bibr68-0269881111408962","volume-title":"Shipley Institute of Living Scale: Revised Manual","author":"Zachary RA","year":"1986"}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0269881111408962","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0269881111408962","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0269881111408962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:07:14Z","timestamp":1777507634000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0269881111408962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,5]]},"references-count":68,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1177\/0269881111408962"],"URL":"https:\/\/doi.org\/10.1177\/0269881111408962","relation":{},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"value":"0269-8811","type":"print"},{"value":"1461-7285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,5]]}}}