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Since spatial memory is altered both by ageing and by benzodiazepines such as alprazolam, we investigated the pharmacological sensitivity of alprazolam-induced deficit in a delayed spatial discrimination (SD) task, notably with positive allosteric modulators of \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors. We showed that alprazolam (0.1\u2009mg\/kg intraperitoneally) induced memory impairments as compared with vehicle-treated mice. The oral administration of modulators of AMPA receptors (IDRA-21: 10\u2009mg\/kg; S18986: 3 and 10\u2009mg\/kg) reversed the alprazolam-induced deficits. This study is first to show evidence that reference treatments of AD, such as memantine (a NMDA receptor antagonist) at 3\u2009mg\/kg per os (po) and donepezil (an acetylcholinesterase inhibitor) at 1\u2009mg\/kg po, also reversed the alprazolam-induced amnesia. Given such results, the SD task emerges as a valuable novel task to screen pro-cognitive compounds. Thus, we highlight the efficacy of modulators of AMPA-type glutamate receptors to counteract alprazolam-induced spatial deficits. These results could be viewed alongside the imbalance between excitation and inhibition observed during normal and pathological ageing.<\/jats:p>","DOI":"10.1177\/0269881111416692","type":"journal-article","created":{"date-parts":[[2011,9,3]],"date-time":"2011-09-03T20:13:21Z","timestamp":1315080801000},"page":"845-856","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of positive modulators of \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors in a benzodiazepine-induced deficit of spatial discrimination in mice"],"prefix":"10.1177","volume":"26","author":[{"given":"M","family":"Vandesquille","sequence":"first","affiliation":[{"name":"Institut de Recherches Servier, Croissy-sur-Seine, France"},{"name":"Institut de Neurosciences Cognitives et Int\u00e9gratives d\u2019Aquitaine, Universit\u00e9s de Bordeaux, Talence, 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