{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T22:07:38Z","timestamp":1787522858320,"version":"build-2736575974"},"reference-count":67,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,1,4]],"date-time":"2012-01-04T00:00:00Z","timestamp":1325635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p>\n                    GSK598809 is a novel selective dopamine D\n                    <jats:sub>3<\/jats:sub>\n                    receptor antagonist, currently in development for the treatment of substance abuse and addiction. In a blinded, randomized, placebo-controlled study, effects of single oral doses of 175 mg GSK598809 were evaluated in healthy volunteers. Pharmacokinetics, central nervous system (CNS) effects and potential for interactions with alcohol were evaluated, using an alcohol infusion paradigm and analysis of eye movements, adaptive tracking, visual analogue scales, body sway, serum prolactin and verbal visual learning test. Adverse effects of GSK598809 included headache, dizziness and somnolence. Plasma concentration of GSK598809 was maximal 2\u20133 hours postdose and decreased with a half-life of roughly 20 hours. CNS effects were limited to prolactin elevation and decreased adaptive tracking. Co-administration of GSK598809 and alcohol did not affect alcohol pharmacokinetics, but caused a 9% decrease of C\n                    <jats:sub>max<\/jats:sub>\n                    and a 15% increase of AUC of GSK598809. CNS effects of co-administration were mainly additive, except a small supra-additive increase in saccadic reaction time and decrease in delayed word recall. In conclusion, GSK598809 causes elevation of serum prolactin and a small decrease in adaptive tracking performance. After co-administration with alcohol, effects of GSK598809 are mainly additive and the combination is well tolerated in healthy volunteers.\n                  <\/jats:p>","DOI":"10.1177\/0269881111431750","type":"journal-article","created":{"date-parts":[[2012,1,5]],"date-time":"2012-01-05T16:22:27Z","timestamp":1325780547000},"page":"303-314","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Pharmacokinetics and central nervous system effects of the novel dopamine D\n                    <sub>3<\/sub>\n                    receptor antagonist GSK598809 and intravenous alcohol infusion at pseudo-steady state"],"prefix":"10.1177","volume":"26","author":[{"given":"ET","family":"te Beek","sequence":"first","affiliation":[{"name":"Centre for Human Drug Research, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RWM","family":"Zoethout","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MSG","family":"Bani","sequence":"additional","affiliation":[{"name":"Neurosciences CEDD, GlaxoSmithKline Research & Development Limited, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Andorn","sequence":"additional","affiliation":[{"name":"Neurosciences CEDD, GlaxoSmithKline Research & Development Limited, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Iavarone","sequence":"additional","affiliation":[{"name":"Neurosciences CEDD, GlaxoSmithKline Research & Development Limited, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ES","family":"Klaassen","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Fina","sequence":"additional","affiliation":[{"name":"Neurosciences CEDD, GlaxoSmithKline Research & Development Limited, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JMA","family":"van Gerven","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,1,4]]},"reference":[{"key":"bibr1-0269881111431750","first-page":"3","volume":"22","author":"Albanese A","year":"1986","journal-title":"J Neural Transm Suppl"},{"key":"bibr2-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.25.11.1065"},{"key":"bibr3-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.154.5.672"},{"key":"bibr4-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.22.6.0451"},{"key":"bibr5-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1983.tb01495.x"},{"key":"bibr6-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1974.tb02285.x"},{"key":"bibr7-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1984.tb02583.x"},{"key":"bibr8-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-37-6-977"},{"key":"bibr9-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-43-4-901"},{"key":"bibr10-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1126\/science.8099761"},{"key":"bibr11-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra023160"},{"key":"bibr12-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1177\/0269881108092595"},{"key":"bibr13-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2001.01308.x"},{"key":"bibr14-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.14.5274"},{"key":"bibr15-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.4.1523"},{"key":"bibr16-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199808000-00007"},{"key":"bibr17-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00125-5"},{"key":"bibr18-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(98)00066-9"},{"key":"bibr19-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2004.12.033"},{"key":"bibr20-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91121-5"},{"key":"bibr21-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.8.1414"},{"key":"bibr22-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1038\/35094560"},{"key":"bibr23-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(05)03491-4"},{"key":"bibr24-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(02)00128-2"},{"key":"bibr25-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1126\/science.2903550"},{"key":"bibr26-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.9.3.482"},{"key":"bibr27-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80557-7"},{"key":"bibr28-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1992.tb00511.x"},{"key":"bibr29-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(93)90188-U"},{"key":"bibr30-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2005.04.022"},{"key":"bibr31-0269881111431750","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0031-6997(24)01327-9","volume":"49","author":"Levant B","year":"1997","journal-title":"Pharmacol Rev"},{"key":"bibr32-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1997.77.2.517"},{"key":"bibr33-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1177\/0269881108094524"},{"key":"bibr34-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.03902.x"},{"key":"bibr35-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1177\/0269881109358200"},{"key":"bibr36-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(83)90001-X"},{"key":"bibr37-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1976.01770030003001"},{"key":"bibr38-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.01.030178.001021"},{"key":"bibr39-0269881111431750","first-page":"1172","volume":"39","author":"Munetz MR","year":"1988","journal-title":"Hosp Community Psychiatry"},{"key":"bibr40-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.23.11271"},{"key":"bibr41-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1038\/nn1578"},{"key":"bibr42-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(71)90039-6"},{"key":"bibr43-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(98)00158-3"},{"key":"bibr44-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.04.016"},{"key":"bibr45-0269881111431750","volume-title":"L\u2019examen clinique en psychologie","author":"Rey A","year":"1964"},{"key":"bibr46-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1177\/026988110001400102"},{"key":"bibr47-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.04.038"},{"key":"bibr48-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20298"},{"key":"bibr49-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(97)00025-9"},{"key":"bibr50-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1970.tb02066.x"},{"key":"bibr51-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200204000-00002"},{"key":"bibr52-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-19-06100.1996"},{"key":"bibr53-0269881111431750","author":"te Beek ET","year":"2011","journal-title":"Journal of Psychopharmacology"},{"key":"bibr54-0269881111431750","author":"te Beek ET","year":"2011","journal-title":"Journal of Psychopharmacology"},{"key":"bibr55-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244655"},{"key":"bibr56-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1991.122"},{"key":"bibr57-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1177\/026988119901300102"},{"key":"bibr58-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1177\/026988119901300406"},{"key":"bibr59-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1053\/snuc.2003.127300"},{"key":"bibr60-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.05.022"},{"key":"bibr61-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001507"},{"key":"bibr62-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.11.1575"},{"key":"bibr63-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1977.tb00229.x"},{"issue":"1","key":"bibr64-0269881111431750","first-page":"27P","volume":"218","author":"Wright BM","year":"1971","journal-title":"J Physiol"},{"key":"bibr65-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.02.014"},{"key":"bibr66-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2009.03488.x"},{"key":"bibr67-0269881111431750","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2008.03268.x"}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0269881111431750","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0269881111431750","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0269881111431750","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:06:59Z","timestamp":1777507619000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0269881111431750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,4]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1177\/0269881111431750"],"URL":"https:\/\/doi.org\/10.1177\/0269881111431750","relation":{},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"value":"0269-8811","type":"print"},{"value":"1461-7285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,4]]}}}