{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:15:24Z","timestamp":1793196924671,"version":"4.5.0"},"reference-count":70,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,2,12]],"date-time":"2012-02-12T00:00:00Z","timestamp":1329004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>The objective of the present study was to examine the effect of long-term management of insulin resistance and hyperglycemia on neurobehavioral deficits in db\/db mice. In this study, 5-week-old db\/db and lean control mice were fed with rosiglitazone (20 mg\/kg\/day) mixed or standard chow for a duration of 5 weeks. Mice were monitored weekly for blood glucose concentration. Five weeks after the onset of treatment, they were subjected to the forced swim test (FST), pre-pulse inhibition (PPI), open field test (OFT) and fear-potentiated startle (FPS) test to examine for depression, psychosis-like behavior, locomotor activity and emotional learning, respectively. Rosiglitazone normalized hyperglycemia and improved glucose tolerance. Rosiglitazone significantly reduced immobility time in the FST in db\/db mice, suggesting an antidepressant-like effect. However, rosiglitazone failed to reverse disruption of PPI in db\/db mice, indicating its ineffectiveness against psychosis-like behavior. In the OFT, rosiglitazone did not affect the activity of db\/db mice, suggesting its antidepressant-like effect was independent of changes in locomotor activity. In the FPS test, db\/db mice showed impaired emotional learning and rosiglitazone failed to correct it. In conclusion, long-term blood glucose management in type-2 diabetics may help to limit the co-occurrence of depression but not the psychotic symptoms and ability to cope with stress.<\/jats:p>","DOI":"10.1177\/0269881111434620","type":"journal-article","created":{"date-parts":[[2012,2,13]],"date-time":"2012-02-13T20:24:31Z","timestamp":1329164671000},"page":"724-732","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":51,"title":["Rosiglitazone treatment reversed depression- but not psychosis-like behavior of\n                    <i>db\/db<\/i>\n                    diabetic mice"],"prefix":"10.1177","volume":"26","author":[{"given":"Ajaykumar N","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid 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