{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:28:07Z","timestamp":1777858087575,"version":"3.51.4"},"reference-count":70,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T00:00:00Z","timestamp":1327881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>\n                    JNJ-37822681 is a novel, fast-dissociating dopamine D\n                    <jats:sub>2<\/jats:sub>\n                    receptor antagonist, currently in development as an antipsychotic drug candidate. A previous first-in-human study demonstrated mild central nervous system effects of JNJ-37822681 in healthy male volunteers. Significant but transient serum prolactin elevations were demonstrated, whereas other neurophysiological effects were relatively small. To investigate striatal dopamine D\n                    <jats:sub>2<\/jats:sub>\n                    receptor occupancy by variable single doses of JNJ-37822681, an open-label [\n                    <jats:sup>11<\/jats:sup>\n                    C]raclopride positron emission tomography study was performed in 12 healthy male volunteers, using the simplified reference tissue model with cerebellum as reference tissue. Oral administration of JNJ-37822681 resulted in dose-dependent dopamine D\n                    <jats:sub>2<\/jats:sub>\n                    receptor occupancy. Receptor occupancy increased from 9\u201319% at 2 mg doses to 60\u201374% at 20 mg doses of JNJ-37822681. Therefore, single oral doses of JNJ-37822681 can produce occupancy levels that are generally associated with clinical efficacy for registered antipsychotic drugs.\n                  <\/jats:p>","DOI":"10.1177\/0269881111435251","type":"journal-article","created":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T01:55:17Z","timestamp":1327974917000},"page":"1128-1135","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["In vivo quantification of striatal dopamine D\n                    <sub>2<\/sub>\n                    receptor occupancy by JNJ-37822681 using [\n                    <sup>11<\/sup>\n                    C]raclopride and positron emission tomography"],"prefix":"10.1177","volume":"26","author":[{"given":"Erik T","family":"te Beek","sequence":"first","affiliation":[{"name":"Centre for Human Drug Research, Leiden, the 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