{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:47:19Z","timestamp":1788792439109,"version":"build-2803163510"},"reference-count":66,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T00:00:00Z","timestamp":1338940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>\n                    Creatine has been shown to play a significant role in health and disease. However, studies concerning its effect on mood are scarce. This study investigated the effect of creatine (p.o.) in the tail suspension test, a predictive test of antidepressant activity. Creatine reduced the immobility time in the tail suspension test (0.1\u20131000 mg\/kg, male and female mice), without affecting locomotor activity. Furthermore, the involvement of the dopaminergic system in creatine-induced antidepressant-like effect in male mice in the tail suspension test was investigated. The anti-immobility effect of creatine (1 mg\/kg) was prevented by the pre-treatment of mice with haloperidol (0.2 mg\/kg, intraperitoneal (i.p.) route, non-selective dopamine receptor antagonist), ( R)-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390; 0.05 mg\/kg, subcutaneous (s.c.) route, dopamine D\n                    <jats:sub>1<\/jats:sub>\n                    receptor antagonist) and sulpiride (50 mg\/kg, i.p., dopamine D\n                    <jats:sub>2<\/jats:sub>\n                    receptor antagonist). Creatine (0.01 mg\/kg, sub-effective dose) in combination with sub-effective doses of (1-phenyl-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepine) hydrochloride (SKF38393; 0.1 mg\/kg, s.c., dopamine D\n                    <jats:sub>1<\/jats:sub>\n                    receptor agonist), apomorphine (0.5 \u00b5g\/kg, i.p., preferential dopamine D\n                    <jats:sub>2<\/jats:sub>\n                    receptor agonist) or bupropion (1 mg\/kg, p.o., dopamine reuptake inhibitor with subtle activity on noradrenergic reuptake) reduced the immobility time in the tail suspension test as compared with either drug alone. These results indicate that the antidepressant-like effect of creatine is likely mediated by an activation of dopamine D\n                    <jats:sub>1<\/jats:sub>\n                    and D\n                    <jats:sub>2<\/jats:sub>\n                    receptors.\n                  <\/jats:p>","DOI":"10.1177\/0269881112447989","type":"journal-article","created":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T00:25:13Z","timestamp":1339028713000},"page":"1489-1501","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Antidepressant-like effect of creatine in mice involves dopaminergic activation"],"prefix":"10.1177","volume":"26","author":[{"given":"Mauricio P","family":"Cunha","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Universidade Federal de Santa Catarina, Florian\u00f3polis, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele G","family":"Machado","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Universidade Federal de Santa Catarina, Florian\u00f3polis, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliano C","family":"Capra","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Universidade Federal de Santa Catarina, Florian\u00f3polis, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jardel","family":"Jacinto","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Universidade Federal de Santa Catarina, Florian\u00f3polis, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis EB","family":"Bettio","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Universidade Federal de Santa Catarina, Florian\u00f3polis, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L\u00facia 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