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Antipsychotic drug\u2019s antagonistic affinity to histamine H\n                    <jats:sub>1<\/jats:sub>\n                    receptors has been identified as a main contributor for weight gain\/obesity side effects. This study therefore investigated whether a combined treatment of betahistine (a H\n                    <jats:sub>1<\/jats:sub>\n                    receptor agonist and H\n                    <jats:sub>3<\/jats:sub>\n                    receptor antagonist) could reduce the body weight\/obesity induced by olanzapine. Female Sprague Dawley rats were treated orally with olanzapine (1 mg\/kg, t.i.d.) and\/or betahistine (2.67 mg\/kg, t.i.d.), or vehicle for two weeks. Rats treated with olanzapine exhibited significant body weight gain and increased food intake. Co-treatment of olanzapine with betahistine significantly prevented (-45%) weight gain and reduced feeding efficiency compared to sole olanzapine treatment. Betahistine treatment alone had no effect on weight gain and food intake. Olanzapine reduced locomotor activity, but not betahistine. These findings demonstrate that olanzapine-induced body weight gain can partially be reduced by co-treatment with betahistine. Betahistine has H\n                    <jats:sub>3<\/jats:sub>\n                    receptor antagonistic effects to increase histamine release, which may augment its direct agonistic effects on H\n                    <jats:sub>1<\/jats:sub>\n                    receptors. These findings have important implications for clinical trials using betahistine to control antipsychotic-induced obesity side effects.\n                  <\/jats:p>","DOI":"10.1177\/0269881112449396","type":"journal-article","created":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T23:29:44Z","timestamp":1339630184000},"page":"1271-1279","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":68,"title":["Reducing olanzapine-induced weight gain side effect by using betahistine: a study in the rat model"],"prefix":"10.1177","volume":"26","author":[{"given":"Chao","family":"Deng","sequence":"first","affiliation":[{"name":"Centre for Translational Neuroscience, School of Health Sciences, University of Wollongong, Wollongong, NSW, Australia"},{"name":"Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia"},{"name":"Schizophrenia Research Institute, Darlinghurst, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiamei","family":"Lian","sequence":"additional","affiliation":[{"name":"Centre for Translational Neuroscience, School of Health Sciences, University of Wollongong, Wollongong, NSW, Australia"},{"name":"Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagesh","family":"Pai","sequence":"additional","affiliation":[{"name":"Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia"},{"name":"Graduate School of Medicine, University of Wollongong, Wollongong, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu-Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Centre for Translational Neuroscience, School of Health Sciences, University of Wollongong, Wollongong, NSW, Australia"},{"name":"Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia"},{"name":"Schizophrenia Research Institute, Darlinghurst, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,6,13]]},"reference":[{"key":"bibr1-0269881112449396","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.001586"},{"key":"bibr2-0269881112449396","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1176\/ajp.156.11.1686","volume":"156","author":"Allison D","year":"1999","journal-title":"Am J Psychiatry"},{"key":"bibr3-0269881112449396","first-page":"C263","volume":"38","author":"Alvarez XA","year":"1993","journal-title":"Inflamm Res"},{"key":"bibr4-0269881112449396","doi-asserted-by":"publisher","DOI":"10.1002\/1099-081X(199911)20:8<369::AID-BDD200>3.0.CO;2-6"},{"key":"bibr5-0269881112449396","first-page":"121","volume":"152","author":"Arjona AA","year":"2004","journal-title":"Behav Brain Res"},{"key":"bibr6-0269881112449396","unstructured":"Australian Government National Health and Medical Research Council (2004) Australian Code of Practice for the Care and Use of Animals for Scientific Purposes, (seventh ed.). 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