{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:44:45Z","timestamp":1778546685241,"version":"3.51.4"},"reference-count":69,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T00:00:00Z","timestamp":1345507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>Rats with chronic inhibition of GABA synthesis by infusion of l-allyglycine, a glutamic acid decarboxylase inhibitor, into their dorsomedial\/perifornical hypothalamus are anxious and exhibit panic-like cardio-respiratory responses to treatment with intravenous (i.v.) sodium lactate (NaLac) infusions, in a manner similar to what occurs in patients with panic disorder. We previously showed that either NMDA receptor antagonists or metabotropic glutamate receptor type 2\/3 receptor agonists can block such a NaLac response, suggesting that a glutamate mechanism is contributing to this panic-like state. Using this animal model of panic, we tested the efficacy of CBiPES and THIIC, which are selective group II metabotropic glutamate type 2 receptor allosteric potentiators (at 10\u201330mg\/kg i.p.), in preventing NaLac-induced panic-like behavioral and cardiovascular responses. The positive control was alprazolam (3mg\/kg i.p.), a clinically effective anti-panic benzodiazepine. As predicted, panic-prone rats given a NaLac challenge displayed NaLac-induced panic-like cardiovascular (i.e. tachycardia and hypertensive) responses and \u201canxiety\u201d (i.e. decreased social interaction time) and \u201cflight\u201d (i.e. increased locomotion) -associated behaviors; however, systemic injection of the panic-prone rats with CBiPES, THIIC or alprazolam prior to the NaLac dose blocked all NaLac-induced panic-like behaviors and cardiovascular responses. These data suggested that in a rat animal model, selective group II metabotropic glutamate type 2 receptor allosteric potentiators show an anti-panic efficacy similar to alprazolam.<\/jats:p>","DOI":"10.1177\/0269881112454230","type":"journal-article","created":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T23:40:47Z","timestamp":1345592447000},"page":"152-161","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Group II metabotropic glutamate receptor type 2 allosteric potentiators prevent sodium lactate-induced panic-like response in panic-vulnerable rats"],"prefix":"10.1177","volume":"27","author":[{"given":"Philip L","family":"Johnson","sequence":"first","affiliation":[{"name":"Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie D","family":"Fitz","sequence":"additional","affiliation":[{"name":"Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric A","family":"Engleman","sequence":"additional","affiliation":[{"name":"Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjell A","family":"Svensson","sequence":"additional","affiliation":[{"name":"Eli Lilly & Co., Indianapolis, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M","family":"Schkeryantz","sequence":"additional","affiliation":[{"name":"Eli Lilly & Co., Indianapolis, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anantha","family":"Shekhar","sequence":"additional","affiliation":[{"name":"Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,8,21]]},"reference":[{"key":"bibr1-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(88)90013-5"},{"key":"bibr2-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1177\/0269881105059253"},{"key":"bibr3-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1080\/15622970802465807"},{"key":"bibr4-0269881112454230","first-page":"362","volume":"27","author":"Bard P","year":"1948","journal-title":"Res Publ Assoc Res Nerv Ment Dis"},{"key":"bibr5-0269881112454230","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-218-44296"},{"key":"bibr6-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01355-0"},{"key":"bibr7-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(91)90077-D"},{"key":"bibr8-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-11-06500.1994"},{"key":"bibr9-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2003.12.079"},{"key":"bibr10-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-33-10691.2003"},{"key":"bibr11-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e32831a473d"},{"key":"bibr12-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00689-X"},{"key":"bibr13-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(88)90267-6"},{"key":"bibr14-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490340612"},{"key":"bibr15-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(80)90012-6"},{"key":"bibr16-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.6.H2891"},{"key":"bibr17-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.6.556"},{"key":"bibr18-0269881112454230","first-page":"28","volume":"64","author":"Gorman JM","year":"2003","journal-title":"J Clin Psych"},{"key":"bibr19-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.4.493"},{"key":"bibr20-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.4.547"},{"key":"bibr21-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1444-8"},{"key":"bibr22-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.07.005"},{"key":"bibr23-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.12.057"},{"key":"bibr24-0269881112454230","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0022-3565(24)37253-2","volume":"284","author":"Helton DR","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr25-0269881112454230","first-page":"3","volume":"57","author":"Hirschfeld RMA","year":"1996","journal-title":"J Clin Psych"},{"key":"bibr26-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2004.09.005"},{"key":"bibr27-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-2099-9"},{"key":"bibr28-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0408-06.2006"},{"key":"bibr29-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301621"},{"key":"bibr30-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2075"},{"key":"bibr31-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.12.1098"},{"key":"bibr32-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950010008002"},{"key":"bibr33-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1993.01820160076009"},{"key":"bibr34-0269881112454230","first-page":"43","volume":"20","author":"Liebowitz MR","year":"1984","journal-title":"Psychopharmacol Bull"},{"key":"bibr35-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.2"},{"key":"bibr36-0269881112454230","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1021\/jm9606756","volume":"40","author":"Monn JA","year":"1997","journal-title":"J Med Chem"},{"key":"bibr37-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)12248-6"},{"key":"bibr38-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2010.10.022"},{"key":"bibr39-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145702003048"},{"key":"bibr40-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90485-X"},{"key":"bibr41-0269881112454230","first-page":"252","volume-title":"J Comp Neurol","volume":"335","author":"Ohishi H","year":"1993"},{"key":"bibr42-0269881112454230","first-page":"735","volume-title":"Neuropharmacol","volume":"38","author":"Parsons CG","year":"1999"},{"key":"bibr43-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00533-1"},{"key":"bibr44-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(94)00129-G"},{"key":"bibr45-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/0924-977X(94)90299-2"},{"key":"bibr46-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1002\/anxi.3070010204"},{"key":"bibr47-0269881112454230","first-page":"1311","volume-title":"Psychopharmacology: The fourth generation of progression","author":"Price LH","year":"1995"},{"key":"bibr48-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1159\/000126174"},{"key":"bibr49-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(97)00009-X"},{"key":"bibr50-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00128-X"},{"key":"bibr51-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00667.2003"},{"key":"bibr52-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(95)00153-N"},{"key":"bibr53-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(01)00060-4"},{"key":"bibr54-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.10.032"},{"key":"bibr55-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1080\/1025389031000146773"},{"key":"bibr56-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2491-06.2006"},{"key":"bibr57-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(94)00307-5"},{"key":"bibr58-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-24-09726.1997"},{"key":"bibr59-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00215-4"},{"key":"bibr60-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(96)00077-9"},{"key":"bibr61-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb07090.x"},{"key":"bibr62-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-19-07503.1997"},{"key":"bibr63-0269881112454230","first-page":"131","volume":"4","author":"Swanson CJ","year":"2005","journal-title":"Nature Rev"},{"key":"bibr64-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.038422"},{"key":"bibr65-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19961202)376:1<143::AID-CNE9>3.0.CO;2-3"},{"key":"bibr66-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(98)00010-1"},{"key":"bibr67-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00698-0"},{"key":"bibr68-0269881112454230","first-page":"11","volume":"47","author":"Weissman MM","year":"1986","journal-title":"J Clin Psych"},{"key":"bibr69-0269881112454230","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(92)90178-I"}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0269881112454230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0269881112454230","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0269881112454230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:07:37Z","timestamp":1777507657000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0269881112454230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,21]]},"references-count":69,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1177\/0269881112454230"],"URL":"https:\/\/doi.org\/10.1177\/0269881112454230","relation":{},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"value":"0269-8811","type":"print"},{"value":"1461-7285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,21]]}}}