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In a double-blind, randomised experiment, 36 males received placebo (12), 50 mg (12) or 100 mg (12) of sumatriptan 2 h before the SPST. Subjective, physiological and hormonal measures were taken before, during and after the test. The dose of 100 mg of sumatriptan increased speech-induced fear more than either a 50mg dose of the drug or placebo. The largest dose of sumatriptan also enhanced vigilance more than placebo, without any change in blood pressure, heart rate or electrical skin conductance. Sumatriptan decreased plasma levels of prolactin. A significant but moderate increase in plasma cortisol after SPST occurred, independent of treatment. Because sumatriptan decreases 5-HT release into the extracellular space, the potentiation of SPST-induced fear caused by the drug supports the hypothesis that 5-HT attenuates this emotional state. As acute administration of antidepressants has also been shown to enhance speaking fear and increase plasma prolactin, in contrast to sumatriptan, the 5-HT regulation of stress-hormone release is likely to be different from that of emotion.<\/jats:p>","DOI":"10.1177\/0269881112472560","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T02:05:36Z","timestamp":1358388336000},"page":"1124-1133","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["The 5-HT1D\/1B receptor agonist sumatriptan enhances fear of simulated speaking and reduces plasma levels of prolactin"],"prefix":"10.1177","volume":"27","author":[{"given":"Marcos Gon\u00e7alves","family":"de Rezende","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Behaviour, Medical School of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, 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