{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:06:42Z","timestamp":1789646802329,"version":"4.0.0"},"reference-count":63,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T00:00:00Z","timestamp":1359417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Heroin addicts consume large quantities of refined sugars. This study investigated the effect of opiate use and antagonism on sweet taste in opiate-maintained drug users and detoxified former chronic opiate users, using a within-subject design.<\/jats:p>\n                  <jats:p>Seven opiate users received methadone and seven buprenorphine maintenance. Six detoxified subjects received naltrexone. Sucrose recognition thresholds and measurements of pleasantness and intensity were determined before and four hours after 1) a single dose of methadone or buprenorphine or 2) naltrexone. Control data were taken from a cohort of healthy volunteers including smokers.<\/jats:p>\n                  <jats:p>All measures of sweet and salt taste perception were significantly greater in opiate users and recently detoxified subjects compared to control subjects, with the exception of sweet pleasantness, which returned to control level after detoxification. Acute methadone administration reduced salt thresholds and unpleasantness to control levels. Increased sweet thresholds and salt unpleasantness in detoxified subjects were reversed by acute opioid antagonism, returning to control levels. These results suggest that opiate use and antagonism alters taste perception. Some of the alterations reverse on detoxification (sweet pleasantness), and others can be reversed by opioid antagonism (sweet threshold, salt unpleasantness). Changes in taste perception may underlie altered consumption of refined sugars in opiate users.<\/jats:p>","DOI":"10.1177\/0269881112472567","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T21:53:00Z","timestamp":1359582780000},"page":"265-275","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Opiate agonists and antagonists modulate taste perception in opiate-maintained and recently detoxified subjects"],"prefix":"10.1177","volume":"27","author":[{"given":"Amy","family":"Green","sequence":"first","affiliation":[{"name":"Psychopharmacology Unit, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Kaul","sequence":"additional","affiliation":[{"name":"Bristol Specialist Drug and Alcohol Service (BSDAS), Avon and Wiltshire Partnership NHS Trust, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacinta","family":"O\u2019Shea","sequence":"additional","affiliation":[{"name":"Bristol Specialist Drug and Alcohol Service (BSDAS), Avon and Wiltshire Partnership NHS Trust, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekta","family":"Sharma","sequence":"additional","affiliation":[{"name":"Bristol Specialist Drug and Alcohol Service (BSDAS), Avon and Wiltshire Partnership NHS Trust, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Bennett","sequence":"additional","affiliation":[{"name":"Schools of Physiology and Pharmacology, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma L","family":"Mullings","sequence":"additional","affiliation":[{"name":"Experimental Psychology, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus R","family":"Munaf\u00f2","sequence":"additional","affiliation":[{"name":"Experimental Psychology, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Nutt","sequence":"additional","affiliation":[{"name":"Psychopharmacology Unit, University of Bristol, Bristol, UK"},{"name":"Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan K","family":"Melichar","sequence":"additional","affiliation":[{"name":"Psychopharmacology Unit, University of Bristol, Bristol, UK"},{"name":"Bristol Specialist Drug and Alcohol Service (BSDAS), Avon and Wiltshire Partnership NHS Trust, Bristol, UK"},{"name":"Schools of Physiology and Pharmacology, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy F","family":"Donaldson","sequence":"additional","affiliation":[{"name":"Schools of Physiology and Pharmacology, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,1,29]]},"reference":[{"key":"bibr1-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1006\/appe.1998.0217"},{"key":"bibr2-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(95)00107-M"},{"key":"bibr3-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(96)00109-4"},{"key":"bibr4-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2004.02.033"},{"key":"bibr5-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"bibr6-0269881112472567","first-page":"R59","volume":"261","author":"Bertino M","year":"1991","journal-title":"Am J Physiol"},{"key":"bibr7-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2004.01.006"},{"key":"bibr8-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(02)00186-2"},{"key":"bibr9-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.07.025"},{"key":"bibr10-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00205-4"},{"key":"bibr11-0269881112472567","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27462Q"},{"key":"bibr12-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/61.6.1206"},{"key":"bibr13-0269881112472567","first-page":"R91","volume":"251","author":"Fantino M","year":"1986","journal-title":"Am J Physiol"},{"key":"bibr14-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2005667"},{"key":"bibr15-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agn122"},{"key":"bibr16-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06033.x"},{"issue":"8","key":"bibr17-0269881112472567","first-page":"S1","volume":"33","author":"Green A","year":"2008","journal-title":"Chem Senses"},{"key":"bibr18-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(02)00758-8"},{"key":"bibr19-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3459-06.2006"},{"key":"bibr20-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(91)90343-Z"},{"key":"bibr21-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.02.041"},{"key":"bibr22-0269881112472567","unstructured":"Kandel ER, Schwartz JH, Jessell TM (2000) Principles of Neural Science. 4th ed. New York: McGraw-Hill Medical, p.1568."},{"key":"bibr23-0269881112472567","first-page":"34","volume":"22","author":"Kaul A","year":"2008","journal-title":"J Psychopharmacol"},{"key":"bibr24-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjl052"},{"key":"bibr25-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(02)00751-5"},{"key":"bibr26-0269881112472567","first-page":"378","volume":"62","author":"Kolarzyk E","year":"2005","journal-title":"Przegl Lek"},{"key":"bibr27-0269881112472567","first-page":"373","volume":"62","author":"Kolarzyk E","year":"2005","journal-title":"Przegl Lek"},{"key":"bibr28-0269881112472567","first-page":"83","volume":"10","author":"Komorowski JM","year":"1986","journal-title":"Int J Obes"},{"key":"bibr29-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.1998.19240557.x"},{"key":"bibr30-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agq101"},{"key":"bibr31-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2503-1"},{"key":"bibr32-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03973-2"},{"key":"bibr33-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(92)90435-5"},{"key":"bibr34-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.08.037"},{"key":"bibr35-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/0891-0618(95)00055-C"},{"key":"bibr36-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/26.7.875"},{"key":"bibr37-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)02872-8"},{"key":"bibr38-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1989.tb00566.x"},{"key":"bibr39-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1177\/0269881109105395"},{"key":"bibr40-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1080\/10826080701517727"},{"key":"bibr41-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.493"},{"key":"bibr42-0269881112472567","first-page":"290","volume":"34","author":"Perl E","year":"1997","journal-title":"Isr J Psychiatry Relat Sci"},{"key":"bibr43-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1002\/food.19910350914"},{"key":"bibr44-0269881112472567","first-page":"604","volume":"24","author":"Prutkin J","year":"1999","journal-title":"Chemical Senses"},{"key":"bibr45-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2007.tb00480.x"},{"key":"bibr46-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4812090"},{"key":"bibr47-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2008.09.001"},{"key":"bibr48-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-007-0247-x"},{"key":"bibr49-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510003971"},{"key":"bibr50-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1080\/00016480260046445"},{"key":"bibr51-0269881112472567","first-page":"397","volume":"52","author":"Scinska A","year":"2000","journal-title":"Pol J Pharmacol"},{"key":"bibr52-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00467-7"},{"key":"bibr53-0269881112472567","volume-title":"Manual for the State-Trait Anxiety Inventory (Form Y)","author":"Spielberger CD","year":"1983"},{"key":"bibr54-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2008.03.013"},{"key":"bibr55-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2002.tb00311.x"},{"key":"bibr56-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6663(83)80045-2"},{"key":"bibr57-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.3.318"},{"key":"bibr58-0269881112472567","doi-asserted-by":"publisher","DOI":"10.3109\/10826088209056337"},{"key":"bibr59-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(96)80017-5"},{"key":"bibr60-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(97)00101-7"},{"key":"bibr61-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(02)00041-6"},{"key":"bibr62-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.56.495"},{"key":"bibr63-0269881112472567","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1996.tb03601.x"}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0269881112472567","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0269881112472567","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0269881112472567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:07:39Z","timestamp":1777507659000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0269881112472567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,29]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1177\/0269881112472567"],"URL":"https:\/\/doi.org\/10.1177\/0269881112472567","relation":{},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"value":"0269-8811","type":"print"},{"value":"1461-7285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,29]]}}}