{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:32:33Z","timestamp":1793082753736,"version":"4.5.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T00:00:00Z","timestamp":1366156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>\n                    Previous results with the elevated T-maze (ETM) test indicate that the antipanic action of serotonin (5-HT) in the dorsal periaqueductal grey (dPAG) depends on the activation endogenous opioid peptides. The aim of the present work was to investigate the interaction between opioid- and serotonin-mediated neurotransmission in the modulation of defensive responses in rats submitted to the ETM. The obtained results showed that intra-dPAG administration of morphine significantly increased escape latency, a panicolytic-like effect that was blocked by pre-treatment with intra-dPAG injection of either naloxone or the 5-HT\n                    <jats:sub>1A<\/jats:sub>\n                    antagonist N-[2-[4-(2-methoxyphenyl)-1 piperazinyl] ethyl] -N- 2- pyridinyl-ciclohexanecarboxamide maleate (WAY-100635). In addition, previous administration of naloxone antagonized both the anti-escape and the anti-avoidance (anxiolytic-like) effect of the 5-HT\n                    <jats:sub>1A<\/jats:sub>\n                    agonist (\u00b1)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-OH-DPAT), but did not affect the anti-escape effect of the 5-HT\n                    <jats:sub>2A<\/jats:sub>\n                    agonist (\u00b1)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI). Moreover, the combination of sub-effective doses of locally administered 5-HT and morphine significantly impaired ETM escape performance. Finally, the \u00b5-antagonist D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN (CTOP) blocked the anti-avoidance as well as the anti-escape effect of 8-OHDPAT, and the association of sub-effective doses of the \u00b5-opioid receptor agonist [D-Ala\n                    <jats:sup>2<\/jats:sup>\n                    , N-Me-Phe\n                    <jats:sup>4<\/jats:sup>\n                    , Gly\n                    <jats:sup>5<\/jats:sup>\n                    -ol]-enkephalin acetate salt (DAMGO) and of 8-OHDPAT had anti-escape and anti-avoidance effects in the ETM. These results suggest a synergic interaction between the 5-HT\n                    <jats:sub>1A<\/jats:sub>\n                    and the \u00b5-opioid receptor at post-synaptic level on neurons of the dPAG that regulate proximal defense, theoretically related to panic attacks.\n                  <\/jats:p>","DOI":"10.1177\/0269881113485144","type":"journal-article","created":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T21:48:42Z","timestamp":1366321722000},"page":"1141-1148","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":41,"title":["Cooperative regulation of anxiety and panic-related defensive behaviors in the rat periaqueductal grey matter by 5-HT\n                    <sub>1A<\/sub>\n                    and \u00b5-receptors"],"prefix":"10.1177","volume":"27","author":[{"given":"Camila M","family":"Roncon","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, Brazil"},{"name":"Instituto de Neuroci\u00eancias e Comportamento (INeC), University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Biesdorf","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norberto C","family":"Coimbra","sequence":"additional","affiliation":[{"name":"Instituto de Neuroci\u00eancias e Comportamento (INeC), University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"},{"name":"Department of Pharmacology, University of S\u00e3o Paulo, Brazil"},{"name":"NAP-NuPNE-N\u00facleo de Apoio \u00e0 Pesquisa em Neurobiologia das Emo\u00e7\u00f5es, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth A","family":"Audi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, Brazil"},{"name":"Instituto de Neuroci\u00eancias e Comportamento (INeC), University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"H\u00e9lio","family":"Zangrossi","sequence":"additional","affiliation":[{"name":"Instituto de Neuroci\u00eancias e Comportamento (INeC), University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"},{"name":"Department of Pharmacology, University of S\u00e3o Paulo, Brazil"},{"name":"NAP-NuPNE-N\u00facleo de Apoio \u00e0 Pesquisa em Neurobiologia das Emo\u00e7\u00f5es, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico G","family":"Graeff","sequence":"additional","affiliation":[{"name":"Instituto de Neuroci\u00eancias e Comportamento (INeC), University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"},{"name":"NAP-NuPNE-N\u00facleo de Apoio \u00e0 Pesquisa em Neurobiologia das Emo\u00e7\u00f5es, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,4,17]]},"reference":[{"key":"bibr1-0269881113485144","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(81)80121-0"},{"key":"bibr2-0269881113485144","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)91068-4"},{"key":"bibr3-0269881113485144","first-page":"193","volume":"77","author":"Beaudet A","year":"1981","journal-title":"J Physiol"},{"key":"bibr4-0269881113485144","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2003.08.001"},{"key":"bibr5-0269881113485144","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchemneu.2006.05.002","volume":"32","author":"Castellan-Baldan L","year":"2006","journal-title":"J Chem 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