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LC neurones project widely to most areas of the neuraxis, where they mediate dual effects: neuronal excitation by \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -adrenoceptors and inhibition by \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    -adrenoceptors. The LC plays an important role in physiological regulatory networks. In the sleep\/arousal network the LC promotes wakefulness, via excitatory projections to the cerebral cortex and other wakefulness-promoting nuclei, and inhibitory projections to sleep-promoting nuclei. The LC, together with other pontine noradrenergic nuclei, modulates autonomic functions by excitatory projections to preganglionic sympathetic, and inhibitory projections to preganglionic parasympathetic neurones. The LC also modulates the acute effects of light on physiological functions (\u2018photomodulation\u2018): stimulation of arousal and sympathetic activity by light via the LC opposes the inhibitory effects of light mediated by the ventrolateral preoptic nucleus on arousal and by the paraventricular nucleus on sympathetic activity. Photostimulation of arousal by light via the LC may enable diurnal animals to function during daytime. LC neurones degenerate early and progressively in Parkinson\u2018s disease and Alzheimer\u2018s disease, leading to cognitive impairment, depression and sleep disturbance.\n                  <\/jats:p>","DOI":"10.1177\/0269881113490326","type":"journal-article","created":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T22:12:35Z","timestamp":1371075155000},"page":"659-693","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":337,"title":["Functional neuroanatomy of the central noradrenergic system"],"prefix":"10.1177","volume":"27","author":[{"given":"Elemer","family":"Szabadi","sequence":"first","affiliation":[{"name":"Division of Psychiatry, University of Nottingham, Nottingham, 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