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However, little is known about somatodendritic 5-HT1A receptors in the median raphe nucleus (MRN). Therefore, the aim of this study was to investigate the role of 5-HT1A receptors located in the MRN in rats exposed to forced swim stress. After recovering from surgery, rats were forced to swim for 15 min in a cylinder. Intra-MRN injections of saline, 8-OH-DPAT (3 nmol\/0.2 \u00b5L) and\/or WAY-100635 (0.3 nmol\/0.2 \u00b5L) were performed immediately before or after pre-exposure or 24 h later (immediately before test). Non-stressed rats received the same treatment 24 h or 10 min before test. Our data showed that 8-OH-DPAT increased latency to display immobility while decreasing time spent immobile in almost all experimental conditions. These effects were not prevented by previous treatment with WAY-100635. No effects of different treatments were described in non-stressed animals. Taken together, our data suggest that in addition to activation of 5-HT1A, 5-HT7 receptors may also be involved in the behavioural consequences of exposure to swim stress.<\/jats:p>","DOI":"10.1177\/0269881113508829","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T21:44:08Z","timestamp":1382737448000},"page":"1134-1140","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Role of serotonin 1A receptors in the median raphe nucleus on the behavioral consequences of forced swim stress"],"prefix":"10.1177","volume":"27","author":[{"given":"PVG","family":"Almeida","sequence":"first","affiliation":[{"name":"Departamento de Psicologia da Faculdade de Filosofia, Ci\u00eancias e Letras de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, 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